一例获得性免疫缺陷综合征患者的乙基肺囊虫肺炎，表现为嗜酸性粒细胞增多和血清TARC/CCL17水平升高。

IF 2 Q3 RESPIRATORY SYSTEM Multidisciplinary Respiratory Medicine Pub Date : 2022-01-12 DOI:10.4081/mrm.2022.802

Yuki Yabuuchi, Masashi Matsuyama, Sosuke Matsumura, Masayuki Nakajima, Yoshihiko Kiyasu, Yuto Takeuchi, Yoshihiko Murata, Ryota Matsuoka, Masayuki Noguchi, Nobuyuki Hizawa

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引用次数: 1

摘要

获得性免疫缺陷综合征(AIDS)患者的乙基肺囊虫肺炎(PCP)表现为嗜酸性肺炎样症状。艾滋病相关PCP引起嗜酸性粒细胞肺炎的详细机制尚未阐明，但有研究表明，乙型肺囊虫的主要成分β - d -葡聚糖和T辅助2型免疫可能参与了肺嗜酸性粒细胞增多的机制。我们经历了一个艾滋病相关PCP患者出现嗜酸性肺炎样疾病的病例，其临床病程表明TARC/CCL17而不是IL-4和IL-5在HIV和乙氏肺囊虫感染引起的嗜酸性粒细胞增多症中的重要性。

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A case of Pneumocystis jirovecii pneumonia in a patient with acquired immune deficiency syndrome who showed eosinophilia and an increased serum TARC/CCL17 level.

Pneumocystis jirovecii pneumonia (PCP) in patients with acquired immune deficiency syndrome (AIDS) shows eosinophilic pneumonia like condition. The detailed mechanisms how AIDS-associated PCP causes eosinophilic pneumonia has not been elucidated, but it has been suggested that beta-D-glucan, a major component of Pneumocystis jirovecii, and T helper type 2 immunity may be involved in the mechanism of eosinophilia in the lung. We experienced the case who developed an eosinophilic pneumonia-like condition in a patient with AIDS-associated PCP, whose clinical course indicated the importance of TARC/CCL17 but not IL-4 and IL-5 as involved in eosinophilia caused by HIV and Pneumocystis jirovecii infection.

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来源期刊

Multidisciplinary Respiratory Medicine 医学-呼吸系统

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.