Brenda M Galindo-Yllu, Ricardo Rojas-Humpire, Carlos J Toro-Huamanchumo, Rosmery Gutierrez-Ajalcriña, Anderson N Soriano
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引用次数: 0
摘要
在一项横断面研究中,我们利用瓦伊坎医院传染病和非传染病预防和监测计划的数据,探讨了秘鲁一家公立医院医务人员的血清尿酸(SUA)与代谢综合征(MetS)和胰岛素抵抗(IR)之间的关系。MetS是根据拉丁美洲糖尿病协会(ALAD)的标准定义的,而IR则是用替代IR标记物、甘油三酯与高密度脂蛋白胆固醇的比率(TG/HDL-C)和甘油三酯与葡萄糖的比率(TyG)来定义的。在平均年龄为 46.2 ± 10.6 岁的 292 名参与者样本中,使用泊松回归模型确定了 SUA 与 MetS 和 IR 之间的关系。MetS 的总患病率为 38%,MetS 患者主要表现为人体测量参数(肥胖和体脂)的改变。最后,调整后的回归模型显示,与 SUA 值最低的女性相比,SUA 值最高的女性的 MetS 患病率更高(PR:1.71,95% CI:1.07-2.74),同时 SUA 会增加男女两性的高甘油三酯血症和 IR(TG/HDL-C 和 TyG)。我们的结论是,SUA 与女性的 MetS 密切相关,SUA 会增加男女两性的高甘油三酯血症和 IR。相反,还需要对女性人群进行更多的研究。
Serum Uric Acid Is Associated with Metabolic Syndrome and Insulin Resistance among Health Personnel from Peru.
We explored the association between serum uric acid (SUA) and metabolic syndrome (MetS) and insulin resistance (IR) among health personnel from a public hospital in Peru in a cross-sectional study with data from the Plan for the Prevention and Surveillance of Communicable and Noncommunicable Diseases of Huaycán Hospital. MetS was defined according to Latin American Diabetes Association (ALAD) criteria and IR with surrogate IR markers, triglyceride-to-HDL-C ratio (TG/HDL-C), and triglyceride-to-glucose index (TyG). The association between SUA and MetS and IR was determined using Poisson regression models in a sample of 292 participants with an average age of 46.2 ± 10.6 years. The total prevalence of MetS was 38%, and the individuals with MetS presented mainly alterations in anthropometric parameters (obesity and body fat). Finally, the adjusted regression models showed that women with SUA in the highest tertile increased the prevalence of MetS (PR: 1.71, 95% CI: 1.07-2.74) compared to the lowest tertile of SUA in women, while SUA increased hypertriglyceridemia and IR (TG/HDL-C and TyG) in both sexes. We concluded that SUA is strongly associated with MetS in women, and SUA increases hypertriglyceridemia and IR in both sexes. On the contrary, more research is required regarding the female population.
期刊介绍:
Journal of Nutrition and Metabolism is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering the broad and multidisciplinary field of human nutrition and metabolism. The journal welcomes submissions on studies related to obesity, diabetes, metabolic syndrome, molecular and cellular biology of nutrients, foods and dietary supplements, as well as macro- and micronutrients including vitamins and minerals.