细胞因子释放综合征- Augmentin超敏反应的独特实体。

IF 1.6 Q3 ALLERGY Asia Pacific Allergy Pub Date : 2022-01-25 eCollection Date: 2022-01-01 DOI:10.5415/apallergy.2022.12.e9

Lynette Liling Tan, May Ping Lee, Si Hui Goh, Hwee Hoon Lim, Anne Goh, Kok Wee Chong

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引用次数: 1

摘要

细胞因子释放综合征(CRS)是一种超敏反应，以前曾与化疗和单克隆抗体有关，但与抗生素有关。我们报告了2例阿莫西林/克拉维酸(Augmentin)过敏性反应类似CRS的儿童病例。我们的两名患者在指数反应期间都表现出类似败血症的急性全身炎症反应的症状。他们的症状在药物激发试验中可重复为过敏反应，但肌肉注射肾上腺素反应不佳。他们的感染检查结果并不显著，疾病遵循一个自我限制的过程。所有这些都指向类似CRS的严重超敏反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cytokine release syndrome - a unique entity of Augmentin hypersensitivity reaction.

Cytokine release syndrome (CRS) is a type of hypersensitivity reaction which has been previously described with chemotherapy and monoclonal antibodies, but not with antibiotics. We present 2 pediatric cases of Amoxicillin/Clavulanic acid (Augmentin) anaphylaxis resembling CRS. Both our patients presented during the index reaction with symptoms suggestive of an acute systemic inflammatory response mimicking sepsis. Their symptomology was reproducible at drug provocation test as anaphylaxis, but with suboptimal response to intramuscular adrenaline. Their infective workups were unremarkable and illnesses followed a self-limiting course. All these point towards a severe hypersensitivity reaction resembling CRS.

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来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.