mTOR复合物1信号通路在糖尿病并发症发病中的作用一个小评论。

IF 1.5 Q3 MEDICINE, RESEARCH & EXPERIMENTAL International Journal of Molecular and Cellular Medicine Pub Date : 2021-01-01 Epub Date: 2022-01-10 DOI:10.22088/IJMCM.BUMS.10.3.181

Amir Yarahmadi, Negar Azarpira, Zohreh Mostafavi-Pour

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引用次数: 4

摘要

哺乳动物雷帕霉素靶蛋白(mTOR)是一种进化上保守的丝氨酸/苏氨酸蛋白激酶，它感知并结合各种环境信号来调节人类细胞的生长和稳态。这条信号通路同步许多关键的细胞过程，并参与越来越多的病理状况，如糖尿病、癌症、肥胖和代谢综合征。在这里，我们回顾了与mTOR复合物1失衡相关的糖尿病并发症。我们进一步讨论了治疗与解除mTOR管制相关的糖尿病并发症的药理学方法。

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Role of mTOR Complex 1 Signaling Pathway in the Pathogenesis of Diabetes Complications; A Mini Review.

The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine-protein kinase that senses and combines various environmental signals to regulate the growth and homeostasis of human cells. This signaling pathway synchronizes many critical cellular processes and is involved in an increasing number of pathological conditions such as diabetes, cancer, obesity, and metabolic syndrome. Here, we review different complications of diabetes that are associated with mTOR complex 1 imbalance. We further discuss pharmacological approaches to treat diabetes complications linked to mTOR deregulation.

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International Journal of Molecular and Cellular Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

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3.60

自引率

0.00%

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期刊介绍： The International Journal of Molecular and Cellular Medicine (IJMCM) is a peer-reviewed, quarterly publication of Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. The journal covers all cellular & molecular biology and medicine disciplines such as the genetic basis of disease, biomarker discovery in diagnosis and treatment, genomics and proteomics, bioinformatics, computer applications in human biology, stem cells and tissue engineering, medical biotechnology, nanomedicine, cellular processes related to growth, death and survival, clinical biochemistry, molecular & cellular immunology, molecular and cellular aspects of infectious disease and cancer research. IJMCM is a free access journal. All open access articles published in IJMCM are distributed under the terms of the Creative Commons Attribution CC BY. The journal doesn''t have any submission and article processing charges (APCs).