甲襞视频毛细血管镜检查在印度人群中结缔组织疾病与雷诺现象。

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Rambam Maimonides Medical Journal Pub Date : 2022-01-27 DOI:10.5041/RMMJ.10460
Sambit Sundaray, Siddhartha Mishra, Subhash Chandra Dash, Naba Kishore Sundaray
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引用次数: 0

摘要

微血管病变以微血管的进行性结构和功能损伤为特征,在各种结缔组织疾病(CTD)的发病机制中起着关键作用。甲襞视频毛细血管镜检查是一种分析微血管异常的最佳和有效的方法,能够区分CTD继发性雷诺现象(RP)与原发性RP和健康受试者。目的:评价和分析印度继发性雷诺患者的甲襞毛细血管镜检查结果,并与健康人的结果进行比较。方法:共有62名研究参与者,包括病例和对照组,接受甲襞视频毛细血管镜检查。毛细血管袢长度、毛细血管宽度、毛细血管密度、是否存在扭曲、巨袢、新生血管生成、微出血和无血管区是研究的参数。结果:所研究的所有定量和定性参数均与二次RP有显著相关。结缔组织疾病患者的平均环路长度明显小于对照组(225.74 μm vs 282.97 μm) (P=0.002)。与对照组相比,这些病例的毛细血管密度也显著降低(4.6对7.39/mm)(结论:定量和定性毛细血管镜改变与继发性RP显著相关。硬皮病型主要见于SSc和MCTD,而非特异性型主要见于SLE和皮肌炎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud's Phenomenon in an Indian Population.

Introduction: Microvasculopathy is characterized by progressive structural and functional damage to the microvessels and plays a key role in the pathogenesis of various connective tissue diseases (CTD). Nailfold videocapillaroscopy is an optimal and validated method for analysis of microvascular abnormalities and is able to differentiate secondary Raynaud's phenomenon (RP) of CTD from primary RP and healthy subjects.

Aim: To assess and analyze nailfold capillaroscopic findings in Indian subjects with secondary Raynaud and to compare with findings in healthy subjects.

Methods: A total of 62 study participants including cases and controls underwent nailfold videocapillaroscopy. Capillary loop length, capillary width, capillary density, presence/absence of tortuosity, giant loops, neoangiogenesis, microhemorrhages, and avascular areas were the parameters studied.

Results: All the quantitative and qualitative parameters studied were significantly associated with secondary RP. Mean loop length in cases of connective tissue diseases was significantly less than in the controls (225.74 μm versus 282.97 μm) (P=0.002). Capillary density was also reduced significantly in the cases as compared to the controls (4.6 versus 7.39/mm) (P<0.01), whereas it was markedly decreased in systemic sclerosis (SSc) and mixed connective tissue diseases (MCTD), and near normal in systemic lupus erythematosus (SLE). Tortuosity was the most frequent (77.4%) qualitative parameter. Scleroderma pattern was found in 62.5% of patients with SSc and in 60% with MCTD. Non-specific pattern was found in 80% of SLE cases and 50% of dermatomyositis cases.

Conclusion: Both quantitative and qualitative capillaroscopic changes are significantly associated with secondary RP. Scleroderma pattern was predominant in SSc and MCTD, whereas non-specific pattern was predominantly found in SLE and dermatomyositis.

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来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
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