miRNA 在牙周炎发病机制中的新作用。

IF 5.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-01 DOI:10.2174/1574888X17666220617103820

Mohammad Taheri, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Sara Tharwat Abdullah, Soudeh Ghafouri-Fard, Arezou Sayad

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引用次数: 1

摘要

人们发现，微小核糖核酸（miRNA）通过调节细胞因子编码基因和其他影响免疫系统活性的分子的表达，参与了多种免疫相关疾病的发病机制。牙周炎就是与多种 miRNA 失调有关的病症之一。在牙周炎患者中，let-7 家族、miR-125、miR-378、miR-543、miR-302、miR-214、miR-200、miR-146、miR-142、miR-30 和 miR-21 等几种 miRNA 均被证明调控失调。在本综述中，我们阐述了 miRNAs 失调对牙周炎病理学的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Emerging Role of miRNAs in the Pathogenesis of Periodontitis.

MicroRNAs (miRNAs) have been found to participate in the pathogenesis of several immune-related conditions through the modulation of the expression of cytokine coding genes and other molecules that affect the activity of the immune system. Periodontitis is an example of these conditions associated with the dysregulation of several miRNAs. Several miRNAs such as let-7 family, miR-125, miR-378, miR-543, miR-302, miR-214, miR-200, miR-146, miR-142, miR-30 and miR-21 have been shown to be dysregulated in patients with periodontitis. miR-146 is the most assessed miRNA in these patients, which is up-regulated in most studies in patients with periodontitis. In the present review, we describe the impact of miRNAs dysregulation on the pathoetiology of periodontitis.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.