COLIA1 sp1结合位点多态性是否使女性易患盆腔器官脱垂?

International urogynecology journal and pelvic floor dysfunction Pub Date : 2009-09-01 Epub Date: 2009-05-07 DOI:10.1007/s00192-009-0895-9

Benjamin Feiner, Fuad Fares, Nail Azam, Ron Auslender, Miriam David, Yoram Abramov

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引用次数: 22

摘要

引言和假设:COLIA1多态性与压力性尿失禁风险增加有关。我们假设类似的关联存在于盆腔器官脱垂(POP)。方法:采用访谈、有效问卷和盆腔检查对晚期脱垂患者和健康对照进行评价。从外周血中提取DNA，并进行聚合酶链反应以确定是否存在多态性。功率计算显示，每组需要36名患者。结果:多态杂合基因型(GT)在研究组和对照组的患病率分别为33.3%和19.4%，优势比为1.75。然而，这种差异没有达到统计学意义(p = 0.27)。结论:COLIA1多态性与POP风险增加无显著相关。

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Does COLIA1 SP1-binding site polymorphism predispose women to pelvic organ prolapse?

Introduction and hypothesis: COLIA1 polymorphism is associated with increased risk for stress urinary incontinence. We hypothesize that a similar association exists with pelvic organ prolapse (POP).

Methods: Patients with advanced prolapse and healthy controls were evaluated by interview, validated questionnaires, and pelvic examination. DNA was extracted from peripheral blood, and polymerase chain reaction was performed to determine the presence or absence of the polymorphism. Power calculation indicated the need for 36 patients in each arm.

Results: The prevalence of the polymorphic heterozygous genotype (GT) in the study and control groups was 33.3% and 19.4%, respectively, leading to an odds ratio of 1.75. This difference, however, did not reach statistical significance (p = 0.27).

Conclusions: The COLIA1 polymorphism was not significantly associated with increased risk for POP.

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