{"title":"HDAC活性对记忆形成的动态影响。","authors":"Nicola M Grissom, Farah D Lubin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Histone deacetylases (HDACs) have previously been shown to be critical for the formation of long-term memories. Recent findings now show that a specific HDAC isoform, HDAC2, negatively regulates formation of hippocampus-dependent memory. These recent findings published in Nature highlight potential new therapeutic interventions for the treatment of memory impairments associated with human neurological disorders.</p>","PeriodicalId":87394,"journal":{"name":"Cellscience","volume":" ","pages":"44-48"},"PeriodicalIF":0.0000,"publicationDate":"2009-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748411/pdf/nihms134941.pdf","citationCount":"0","resultStr":"{\"title\":\"The dynamics of HDAC activity on memory formation.\",\"authors\":\"Nicola M Grissom, Farah D Lubin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Histone deacetylases (HDACs) have previously been shown to be critical for the formation of long-term memories. Recent findings now show that a specific HDAC isoform, HDAC2, negatively regulates formation of hippocampus-dependent memory. These recent findings published in Nature highlight potential new therapeutic interventions for the treatment of memory impairments associated with human neurological disorders.</p>\",\"PeriodicalId\":87394,\"journal\":{\"name\":\"Cellscience\",\"volume\":\" \",\"pages\":\"44-48\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2009-07-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748411/pdf/nihms134941.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellscience\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellscience","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The dynamics of HDAC activity on memory formation.
Histone deacetylases (HDACs) have previously been shown to be critical for the formation of long-term memories. Recent findings now show that a specific HDAC isoform, HDAC2, negatively regulates formation of hippocampus-dependent memory. These recent findings published in Nature highlight potential new therapeutic interventions for the treatment of memory impairments associated with human neurological disorders.
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