STUDIES IN DENERVATION: A.-METHODS.

Introduction IT is proposed to report under the above general heading a number of investigations on patients with peripheral nerve lesions. The following titles indicate the nature of the papers. A. Methods. B. The Circulation in Denervated Digits. C. Inflammation and Trophic Ulcers in Denervated Areas. D. The Mechanism of Axonal Vasodilatation. E. Observations Concerning Adrenaline. F. The Circulation of the Skin of the Proximal Parts of the Limbs. G. Sebaceous Secretion. H. The Effect of Electrical Treatment on the Circulation and Recovery of Denervated Muscles. I. The Contractilityand Excitability of Denervated Muscle. The original intention of bringing these studies within the compass of one or two papers has been found impractical and for convenience of presentation and of reference the work has been divided into sections. These sections will be found to be of unequal merit as some merely report incidental observations which have not been elaborated. Another disadvantage of this method of presentation is that it leads to unnecessary repetition. This, however, has been obviated by the Editor who has kindly arranged to publish the papers seriatim. This grouping permits a single description of the patients and methods to suffice for the majority of these studies and allows of ready reference between papers. It is the purpose of the present paper to describe the methods and the subjects used in these investigations.