限制果糖摄入对体重和血压昼夜节律的影响

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-03-29 DOI:10.1155/2012/459087
Danielle Senador, Swapnil Shewale, Maria Claudia Irigoyen, Khalid M Elased, Mariana Morris
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引用次数: 8

摘要

众所周知,高果糖饮食会导致心血管和代谢疾病。目的是确定摄入高果糖(10%液体溶液)的时间是否会影响代谢和心血管结果。用无线电遥测探针将雄性C57BL小鼠分为四组:(1)24 h水(对照组);(2) 24 h果糖(F24);(3)光期12 h果糖(F12L);(4)暗期12h果糖(F12D)。所有果糖组都有更高的液体摄入量。进食受限的小鼠体重增加,但总热量摄入没有差异。限制进入组的空腹血糖较高。F24小鼠在黑暗期表现出果糖诱导的血压升高。F12L小鼠的血压昼夜节律不存在。结果表明,果糖摄入的时间是高果糖摄入引起的心血管和代谢病理病因学的重要变量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Effects of restricted fructose access on body weight and blood pressure circadian rhythms.
High-fructose diet is known to produce cardiovascular and metabolic pathologies. The objective was to determine whether the timing of high fructose (10% liquid solution) intake affect the metabolic and cardiovascular outcomes. Male C57BL mice with radiotelemetric probes were divided into four groups: (1) 24 h water (control); (2) 24 h fructose (F24); (3) 12 h fructose during the light phase (F12L); (4) 12 h fructose during the dark phase (F12D). All fructose groups had higher fluid intake. Body weight was increased in mice on restricted access with no difference in total caloric intake. Fasting glycemia was higher in groups with restricted access. F24 mice showed a fructose-induced blood pressure increase during the dark period. Blood pressure circadian rhythms were absent in F12L mice. Results suggest that the timing of fructose intake is an important variable in the etiology of cardiovascular and metabolic pathologies produced by high fructose consumption.
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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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