一切都在血液中:循环祖细胞在糖尿病并发症中的多方面贡献。

Experimental Diabetes Research Pub Date : 2012-01-01 Epub Date: 2012-04-03 DOI:10.1155/2012/742976
Gian Paolo Fadini, Angelo Avogaro
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引用次数: 0

摘要

糖尿病(DM)是一种全球范围内日益增长的疾病,由于其并发症带来的负担,它已成为一个巨大的社会和医疗保健问题。微血管和大血管糖尿病并发症是通过众所周知的生化途径造成过度损伤而引起的。有趣的是,微血管病变会侵袭骨髓(BM)微环境,其特征与视网膜病变、肾病变和神经病变相似。骨髓是多系祖细胞的储备库,不仅限于造血系统,还包括内皮细胞、平滑肌细胞、心肌细胞和成骨细胞。人类和动物模型患糖尿病时,所有这些多系祖细胞都会发生严重变化。内皮祖细胞(EPCs)的减少以及平滑肌祖细胞(SMP)和成骨细胞的过剩造成了失衡,从而促进了微血管和大血管病变的发展。最后,在动物模型中发现,过量生成的生化细胞会导致糖尿病并发症。综上所述,越来越多的文献认为循环祖细胞在糖尿病的病理生理学中扮演着多方面的角色,这为将基础母细胞和血液置于舞台中心提出了新的设想。
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It is all in the blood: the multifaceted contribution of circulating progenitor cells in diabetic complications.

Diabetes mellitus (DM) is a worldwide growing disease and represents a huge social and healthcare problem owing to the burden of its complications. Micro- and macrovascular diabetic complications arise from excess damage through well-known biochemical pathways. Interestingly, microangiopathy hits the bone marrow (BM) microenvironment with features similar to retinopathy, nephropathy and neuropathy. The BM represents a reservoir of progenitor cells for multiple lineages, not limited to the hematopoietic system and including endothelial cells, smooth muscle cells, cardiomyocytes, and osteogenic cells. All these multiple progenitor cell lineages are profoundly altered in the setting of diabetes in humans and animal models. Reduction of endothelial progenitor cells (EPCs) along with excess smooth muscle progenitor (SMP) and osteoprogenitor cells creates an imbalance that promote the development of micro- and macroangiopathy. Finally, an excess generation of BM-derived fusogenic cells has been found to contribute to diabetic complications in animal models. Taken together, a growing amount of literature attributes to circulating progenitor cells a multi-faceted role in the pathophysiology of DM, setting a novel scenario that puts BM and the blood at the centre of the stage.

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来源期刊
Experimental Diabetes Research
Experimental Diabetes Research 医学-内分泌学与代谢
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审稿时长
3-8 weeks
期刊最新文献
Nontraditional Therapy of Diabetes and Its Complications In Vitro Investigation and Evaluation of Novel Drug Based on Polyherbal Extract against Type 2 Diabetes Prevalence and Risk Factors Associated with Type 2 Diabetes in Elderly Patients Aged 45-80 Years at Kanungu District Erratum to “Circulating Levels of MicroRNA from Children with Newly Diagnosed Type 1 Diabetes and Healthy Controls: Evidence That miR-25 Associates to Residual Beta-Cell Function and Glycaemic Control during Disease Progression” A PEDF-derived peptide inhibits retinal neovascularization and blocks mobilization of bone marrow-derived endothelial progenitor cells.
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