Natasha Tiffany Strande, Crystal Ann Waters, Dale A Ramsden
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Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?
The Nonhomologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmentally-programmed recombinations that are required for adaptive immunity. Chromosome breaks often have complex or "dirty" end structures that can interfere with the critical ligation step in this pathway; we review here how Nonhomologous end joining resolves such breaks.
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