Wesam Ahmed Nasif, Abeer Shaker El-Moursy Ali, Mohammed Hasan Mukhtar, Aali Marzouq H Alhuzali, Yahya Ahmed Yahya Alnashri, Ziyad Ishaq Ahmed Gadah, Eyyad Adeeb A Edrees, Hussam Abdulaziz Mabruk Albarakati, Hussam Saud Muhji Aloufi
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In addition, we assessed the efficiency of anticoagulant therapies in reducing COVID-19 severity and improving the prognosis of the patients.</p><p><strong>Materials and methods: </strong>A comprehensive literature review was conducted using MEDLINE/PubMed databases, Scopus, and Web of Science with the help of keywords \"COVID-19,\" \"D-Dimer,\" \"Thrombosis,\" \"Fibrin network,\" \"Anticoagulant therapy,\" \"Inflammation,\" and \"disease severity.\" Based on all these articles and clinical experience, a scoping review was constructed and the full texts of the articles that were retrieved were accessed.</p><p><strong>Results: </strong>A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. Thus, it serves as a marker of thrombotic activity. 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The levels of D-dimer have been postulated to be positively associated with the degree of disease severity among COVID-19 patients.</p><p><strong>Conclusions: </strong>It has been postulated that D-dimer could potentially be used as a biomarker to predict the prognosis and outcome of COVID-19 patients at the time of admission to hospitals and facilitate more personalized and efficient clinical management that could significantly reduce the mortality rate of such patients and allow more rapid recovery.</p>","PeriodicalId":46055,"journal":{"name":"Anemia","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2022-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8924600/pdf/","citationCount":"11","resultStr":"{\"title\":\"Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review.\",\"authors\":\"Wesam Ahmed Nasif, Abeer Shaker El-Moursy Ali, Mohammed Hasan Mukhtar, Aali Marzouq H Alhuzali, Yahya Ahmed Yahya Alnashri, Ziyad Ishaq Ahmed Gadah, Eyyad Adeeb A Edrees, Hussam Abdulaziz Mabruk Albarakati, Hussam Saud Muhji Aloufi\",\"doi\":\"10.1155/2022/9104209\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>The review explores the findings of previous studies to elucidate the association between levels of D-dimer and COVID-19 severity and prognosis. 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引用次数: 11
摘要
目的:回顾以往的研究结果,阐明d -二聚体水平与COVID-19严重程度和预后之间的关系。此外,我们还评估了抗凝治疗在降低COVID-19严重程度和改善患者预后方面的效果。材料和方法:使用MEDLINE/PubMed数据库、Scopus和Web of Science,检索关键词“COVID-19”、“d -二聚体”、“血栓形成”、“纤维蛋白网络”、“抗凝治疗”、“炎症”和“疾病严重程度”,进行全面的文献综述。基于所有这些文章和临床经验,构建了一个范围综述,并访问了检索到的文章的全文。结果:d -二聚体是在纤溶酶介导的纤维蛋白网络降解过程中形成的一种复杂的蛋白质分子。因此,它可以作为血栓活性的标志。另一方面,除了严重呼吸窘迫和肺气体交换减少外,严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)也会引发感染者的血栓前变化。d -二聚体水平被认为与COVID-19患者疾病严重程度呈正相关。结论:d -二聚体有可能作为一种生物标志物,在入院时预测COVID-19患者的预后和转归,促进更个性化和高效的临床管理,从而显著降低此类患者的死亡率,并使其更快康复。
Elucidating the Correlation of D-Dimer Levels with COVID-19 Severity: A Scoping Review.
Aims: The review explores the findings of previous studies to elucidate the association between levels of D-dimer and COVID-19 severity and prognosis. In addition, we assessed the efficiency of anticoagulant therapies in reducing COVID-19 severity and improving the prognosis of the patients.
Materials and methods: A comprehensive literature review was conducted using MEDLINE/PubMed databases, Scopus, and Web of Science with the help of keywords "COVID-19," "D-Dimer," "Thrombosis," "Fibrin network," "Anticoagulant therapy," "Inflammation," and "disease severity." Based on all these articles and clinical experience, a scoping review was constructed and the full texts of the articles that were retrieved were accessed.
Results: A D-dimer is a complex protein molecule that is formed during plasmin-mediated degradation of the fibrin network. Thus, it serves as a marker of thrombotic activity. On the other hand, in addition to severe respiratory distress and reduction in pulmonary gas exchange, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) also triggers prothrombotic changes in the infected individuals. The levels of D-dimer have been postulated to be positively associated with the degree of disease severity among COVID-19 patients.
Conclusions: It has been postulated that D-dimer could potentially be used as a biomarker to predict the prognosis and outcome of COVID-19 patients at the time of admission to hospitals and facilitate more personalized and efficient clinical management that could significantly reduce the mortality rate of such patients and allow more rapid recovery.
期刊介绍:
Anemia is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies on all types of anemia. Articles focusing on patient care, health systems, epidemiology, and animal models will be considered, among other relevant topics. Affecting roughly one third of the world’s population, anemia is a major public health concern. The journal aims to facilitate the exchange of research addressing global health and mortality relating to anemia and associated diseases.