Julie Marie Brandt, Nicoline Hemager, Maja Gregersen, Anne Søndergaard, Mette Falkenberg Krantz, Jessica Ohland, Martin Wilms, Sinnika Birkehøj Rohd, Carsten Hjorthøj, Lotte Veddum, Christina Bruun Knudsen, Anna Krogh Andreassen, Aja Greve, Katrine Søborg Spang, Camilla Austa Christiani, Ditte Ellersgaard, Birgitte Klee Burton, Ditte Lou Gantriis, Vibeke Bliksted, Ole Mors, Kerstin Jessica Plessen, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Anne Amalie Elgaard Thorup
{"title":"精神分裂症或双相情感障碍家族性高风险儿童的童年创伤:一项纵向研究。丹麦高风险和恢复力研究- VIA 7和VIA 11","authors":"Julie Marie Brandt, Nicoline Hemager, Maja Gregersen, Anne Søndergaard, Mette Falkenberg Krantz, Jessica Ohland, Martin Wilms, Sinnika Birkehøj Rohd, Carsten Hjorthøj, Lotte Veddum, Christina Bruun Knudsen, Anna Krogh Andreassen, Aja Greve, Katrine Søborg Spang, Camilla Austa Christiani, Ditte Ellersgaard, Birgitte Klee Burton, Ditte Lou Gantriis, Vibeke Bliksted, Ole Mors, Kerstin Jessica Plessen, Jens Richardt Møllegaard Jepsen, Merete Nordentoft, Anne Amalie Elgaard Thorup","doi":"10.1111/bjc.12364","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objectives</h3>\n \n <p>Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).</p>\n </section>\n \n <section>\n \n <h3> Design</h3>\n \n <p>The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>A cohort of 512 children at FHR-SZ (<i>N </i>= 199), FHR-BP (<i>N </i>= 118), and PBCs (<i>N </i>= 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (<i>N </i>= 172), FHR-BP (<i>N </i>= 104), and PBCs (<i>N </i>= 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0–11 years) compared with PBCs (OR 2.082, 95%CI 1.223–3.545, <i>p</i> = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29–1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26–1.85; PBCs: observed mean: 0.99, 95%CI 0.82–1.17; <i>p</i> < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0–11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122–6.710, <i>p</i> < .001; FHR-BP: OR 3.602, 95%CI 1.913–6.783, <i>p</i> < .001).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.</p>\n </section>\n </div>","PeriodicalId":48211,"journal":{"name":"British Journal of Clinical Psychology","volume":"61 4","pages":"875-894"},"PeriodicalIF":3.8000,"publicationDate":"2022-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":"{\"title\":\"Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. 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引用次数: 4
摘要
童年创伤会增加患精神疾病的风险，父母患有精神分裂症或双相情感障碍也是如此。我们的目的是比较家族性精神分裂症(FHR-SZ)或双相情感障碍(FHR-BP)高风险的11岁儿童与基于人群的对照组(pbc)的终生儿童创伤患病率。本研究是一项纵向、前瞻性队列研究，研究对象为FHR-SZ、FHR-BP和pbc患儿。方法选取基线时FHR-SZ患儿512例(N = 199)、FHR-BP患儿118例(N = 118)、pbc患儿195例(平均年龄7.8岁，SD 0.2)， 4年随访时FHR-SZ患儿172例(N = 172)、FHR-BP患儿104例(N = 104)、pbc患儿175例(平均年龄11.9岁，SD 0.2，保留率87.3%)。儿童创伤是通过半结构化访谈来测量的。结果与PBCs相比，FHR-BP患儿暴露于任何终身创伤(0-11岁)的风险较高(OR 2.082, 95%CI 1.223-3.545, p = 0.007)。单因素方差分析显示，与PBCs相比，两个fhr组都有更高的终生暴露于更多类型创伤的患病率(FHR-SZ:观察平均值:1.53,95%CI 1.29-1.77;FHR-BP:观察平均值:1.56,95%CI 1.26-1.85;PBCs:观察平均值:0.99,95%CI 0.82-1.17;p & lt;措施)。二元logistic回归分析显示，两组儿童终生暴露于人际创伤(0 ~ 11岁)的风险均升高(FHR-SZ: OR 3.773, 95%CI 2.122 ~ 6.710, p <措施;FHR-BP: OR 3.602, 95%CI 1.913-6.783, p <措施)。结论:与PBCs相比，FHR-SZ和FHR-BP组儿童暴露于儿童创伤的风险更高。这项研究强调了在FHR-SZ和FHR-BP患儿中早期发现、支持和预防儿童创伤的必要性。
Childhood trauma in children at familial high risk of schizophrenia or bipolar disorder: A longitudinal study. The Danish High Risk and Resilience Study – VIA 7 and VIA 11
Objectives
Childhood trauma increases the risk of developing mental illness as does being born to parents with schizophrenia or bipolar disorder. We aimed to compare prevalence of lifetime childhood trauma among 11-year-old children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) compared with population-based controls (PBCs).
Design
The study is a longitudinal, prospective cohort study of children at FHR-SZ, FHR-BP, and PBCs.
Methods
A cohort of 512 children at FHR-SZ (N = 199), FHR-BP (N = 118), and PBCs (N = 195) were examined at baseline (mean age 7.8, SD 0.2) and 451 children at FHR-SZ (N = 172), FHR-BP (N = 104), and PBCs (N = 175) were examined at four-year follow-up (mean age 11.9, SD 0.2, retention rate 87.3%). Childhood trauma was measured with a semi-structured interview.
Results
Children at FHR-BP had an elevated risk of exposure to any lifetime trauma (age 0–11 years) compared with PBCs (OR 2.082, 95%CI 1.223–3.545, p = .007) measured with binary logistic regression. One-way ANOVA revealed that both FHR-groups had a higher lifetime prevalence of exposure to a greater number of types of trauma compared with PBCs (FHR-SZ: observed mean: 1.53, 95%CI 1.29–1.77; FHR-BP: observed mean: 1.56, 95%CI 1.26–1.85; PBCs: observed mean: 0.99, 95%CI 0.82–1.17; p < .001). Binary logistic regression showed that the lifetime risk of exposure to interpersonal trauma (age 0–11 years) was elevated for both FHR-groups (FHR-SZ: OR 3.773, 95%CI 2.122–6.710, p < .001; FHR-BP: OR 3.602, 95%CI 1.913–6.783, p < .001).
Conclusions
Children at FHR-SZ and FHR-BP are at increased risk for being exposed to childhood trauma compared with PBCs. This study underscores the need for early detection, support, and prevention of childhood trauma in children at FHR-SZ and FHR-BP.
期刊介绍：
The British Journal of Clinical Psychology publishes original research, both empirical and theoretical, on all aspects of clinical psychology: - clinical and abnormal psychology featuring descriptive or experimental studies - aetiology, assessment and treatment of the whole range of psychological disorders irrespective of age group and setting - biological influences on individual behaviour - studies of psychological interventions and treatment on individuals, dyads, families and groups
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