乙型肝炎相关肝细胞癌患者的长期生存和危险因素:一项真实世界研究

IF 2.7 4区 医学 Q2 Medicine Canadian Journal of Gastroenterology and Hepatology Pub Date : 2022-08-23 eCollection Date: 2022-01-01 DOI:10.1155/2022/7750140
Yu Zhu, Ling-Ling Gu, Fa-Biao Zhang, Guo-Qun Zheng, Ting Chen, Wei-Dong Jia
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引用次数: 0

摘要

回顾性队列研究收集2012年1月1日至2018年8月31日在中国科学技术大学第一附属医院行根治性肝切除术的465例乙型肝炎相关肝细胞癌患者。收集临床、病理和随访资料,比较根治性切除术后死亡和非死亡的基本特征。Kaplan-Meier曲线用于生存分析和男女亚组分析。采用多因素Cox比例风险回归模型分析与术后死亡相关的独立危险因素。465例乙肝相关肝细胞癌根治术患者中,132例死亡,术后1年、3年、5年累计生存率分别为92.1%、78%、64%。在男性和女性亚组中,分别有115例和17例患者死亡。男性1年、3年和5年累积生存率分别为92.6%、77.0%和62.6%,女性分别为89.6%、78.8%和70.2%。多因素Cox比例风险回归分析显示,微血管侵犯(MVI)、Edmondson III/IV期、BCLC分期B期、总胆红素(TB) > 20.5 μmol/L是乙型肝炎相关肝癌根治性肝切除术后发生的独立危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Long-Term Survival and Risk Factors in Patients with Hepatitis B-Related Hepatocellular Carcinoma: A Real-World Study.

A retrospective cohort study was conducted to collect 465 patients with hepatitis B-related hepatocellular carcinoma who had undergone radical hepatectomy from January 1, 2012, to August 31, 2018, at the First Affiliated Hospital of the University of Science and Technology of China. The clinical, pathological, and follow-up information was collected to compare the basic characteristics of death and nondeath after radical resection. Kaplan-Meier curves were used for survival analysis and male and female subgroup analysis. The multivariate Cox proportional-hazards regression model was used to analyze independent risk factors related to postoperative death. Of the 465 patients with radical resection of hepatitis B-related hepatocellular carcinoma, 132 died, and 1-, 3-, and 5-year cumulative survival rates after operation were 92.1%, 78%, and 64%, respectively. In the male and female subgroup, 115 and 17 patients died, respectively. The 1-, 3-, and 5-year cumulative survival rates were 92.6%, 77.0%, and 62.6%, respectively, in men, and 89.6%, 78.8%, and 70.2%, respectively, in women. Multivariate Cox proportional-hazards regression analysis showed that microvascular invasion (MVI), Edmondson III/IV, BCLC stage B, and total bilirubin (TB) > 20.5 μmol/L were independent risk factors in patients with hepatitis B-related hepatocellular carcinoma after radical hepatectomy.

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来源期刊
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
37 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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