用BD Onclarity HPV检测方法鉴定多重人乳头瘤病毒(HPV)感染的特征评价,并与单一HPV感染的比较

IF 1.7 Q3 PATHOLOGY Journal of Pathology and Translational Medicine Pub Date : 2022-09-01 Epub Date: 2022-09-13 DOI:10.4132/jptm.2022.08.02
Jinhee Kim, Moonsik Kim, Ji Young Park
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引用次数: 3

摘要

背景:人乳头瘤病毒(HPV)感染是宫颈癌及其相关前驱病变的主要原因。多种HPV基因型感染已被报道。然而,他们的临床病理特征仍然难以捉摸。方法:本研究回顾性选择814例连续接受阴道镜检查并使用BD Onclarity HPV检测进行HPV基因分型检测的患者。比较多发HPV感染与单一HPV感染的临床病理参数。结果:814例患者中有110例存在多发HPV感染,占13.5%。与单一HPV感染相比,多发HPV感染与高级别上皮内病变(HSILs)的发生率显著升高相关。除HPV 16外,其他高危HPV基因型在多发HPV感染组中更为常见;包括HPV 51、52、33/58、56/59/66和35/39/68。未发现特定的合并感染模式。此外,多重HPV感染中HPV基因型的数量与HSIL或鳞状细胞癌的进展无关。结论:多发HPV感染具有明显的临床病理特征(与单一HPV感染相比)。由于它们的生物学行为是不确定的,因此需要密切和频繁的随访。
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Evaluation of the characteristics of multiple human papillomavirus (HPV) infections identified using the BD Onclarity HPV assay and comparison with those of single HPV infection.

Background: Human papillomavirus (HPV) infection is a major cause of cervical cancer and associated precursor lesions. Multiple HPV genotype infections have been reported. However, their clinicopathological characteristics still remain elusive.

Methods: For this study, 814 consecutive patients who had undergone colposcopy and HPV genotyping test using BD Onclarity HPV assay were retrospectively selected. Clinicopathological parameters of multiple HPV infections were compared with those of single HPV infection.

Results: Multiple HPV infections were found in 110 out of 814 cases (13.5%). Multiple HPV infections were associated with a significantly higher incidence of high-grade intraepithelial lesions (HSILs) compared with single HPV infection. Other high-risk HPV genotypes, in addition to HPV 16, were found more frequently in the multiple HPV infections group; these included HPV 51, 52, 33/58, 56/59/66, and 35/39/68. No specific coinfection pattern was not identified. Additionally, the number of HPV genotypes in multiple HPV infections was not associated with the progression to HSIL or squamous cell carcinoma.

Conclusions: Multiple HPV infections have distinct clinicopathological characteristics (compared with single HPV infection). As their biological behavior is uncertain, close and frequent follow-up is warranted.

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来源期刊
CiteScore
5.00
自引率
4.20%
发文量
45
审稿时长
14 weeks
期刊介绍: The Journal of Pathology and Translational Medicine is an open venue for the rapid publication of major achievements in various fields of pathology, cytopathology, and biomedical and translational research. The Journal aims to share new insights into the molecular and cellular mechanisms of human diseases and to report major advances in both experimental and clinical medicine, with a particular emphasis on translational research. The investigations of human cells and tissues using high-dimensional biology techniques such as genomics and proteomics will be given a high priority. Articles on stem cell biology are also welcome. The categories of manuscript include original articles, review and perspective articles, case studies, brief case reports, and letters to the editor.
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