{"title":"彩色多普勒超声对早期糖尿病肾病的诊断价值。","authors":"Linshen Ke, Yanyan Guo, Xiuli Geng","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Early diagnosis of diabetic nephropathy (DN), the leading cause of death in diabetic patients, is an important issue in preventing and reducing the disease burden for patients and the healthcare system. In this study, we aimed at investigating the value of color doppler ultrasonography in the diagnosis of early diabetic nephropathy (DN).</p><p><strong>Methods: </strong>Two hundred and thirty-eight diabetic patients, were enrolled in this study and were categorized into, either control (n = 109) or study group (n = 129), according to 24 hours urinary albumin excretion rate (UAER), from January 2015 to March 2021. The morphologic findings of the kidneys were observed and compared, in both groups, by color doppler ultrasound technique, and blood flow of renal arteries was also measured, at all levels. Fasting plasma glucose (FPG), uric acid, homocysteine, beta-2- microglobulin, cystatin C, hemoglobin A1c (HbA1c) and CRP were also extracted from their laboratory results.</p><p><strong>Results: </strong>Compared to the control group, the study group had lower intrarenal arterial end-diastolic blood flow velocity (EDV) and higher arterial resistance index (RI) (P ~ < .05). A significant diagnostic value of intrarenal arterial EDV and RI was found for early detection of DN (P ~ < .05). Intrarenal arterial RI and EDV showed positive correlations with UAER, FPG, uric acid, homocysteine, beta-2-microglobulin, cystatin C, HbA1c, and CRP (P ~ < .05).</p><p><strong>Conclusion: </strong>Color doppler ultrasound markers of renal and intrarenal arteries has a high diagnostic value for DN at its early stage. DOI: 10.52547/ijkd.7246.</p>","PeriodicalId":14610,"journal":{"name":"Iranian journal of kidney diseases","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Value of Color Doppler Ultrasonography for Diagnosing Early Diabetic Nephropathy.\",\"authors\":\"Linshen Ke, Yanyan Guo, Xiuli Geng\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Early diagnosis of diabetic nephropathy (DN), the leading cause of death in diabetic patients, is an important issue in preventing and reducing the disease burden for patients and the healthcare system. In this study, we aimed at investigating the value of color doppler ultrasonography in the diagnosis of early diabetic nephropathy (DN).</p><p><strong>Methods: </strong>Two hundred and thirty-eight diabetic patients, were enrolled in this study and were categorized into, either control (n = 109) or study group (n = 129), according to 24 hours urinary albumin excretion rate (UAER), from January 2015 to March 2021. The morphologic findings of the kidneys were observed and compared, in both groups, by color doppler ultrasound technique, and blood flow of renal arteries was also measured, at all levels. Fasting plasma glucose (FPG), uric acid, homocysteine, beta-2- microglobulin, cystatin C, hemoglobin A1c (HbA1c) and CRP were also extracted from their laboratory results.</p><p><strong>Results: </strong>Compared to the control group, the study group had lower intrarenal arterial end-diastolic blood flow velocity (EDV) and higher arterial resistance index (RI) (P ~ < .05). A significant diagnostic value of intrarenal arterial EDV and RI was found for early detection of DN (P ~ < .05). Intrarenal arterial RI and EDV showed positive correlations with UAER, FPG, uric acid, homocysteine, beta-2-microglobulin, cystatin C, HbA1c, and CRP (P ~ < .05).</p><p><strong>Conclusion: </strong>Color doppler ultrasound markers of renal and intrarenal arteries has a high diagnostic value for DN at its early stage. DOI: 10.52547/ijkd.7246.</p>\",\"PeriodicalId\":14610,\"journal\":{\"name\":\"Iranian journal of kidney diseases\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian journal of kidney diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian journal of kidney diseases","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Value of Color Doppler Ultrasonography for Diagnosing Early Diabetic Nephropathy.
Introduction: Early diagnosis of diabetic nephropathy (DN), the leading cause of death in diabetic patients, is an important issue in preventing and reducing the disease burden for patients and the healthcare system. In this study, we aimed at investigating the value of color doppler ultrasonography in the diagnosis of early diabetic nephropathy (DN).
Methods: Two hundred and thirty-eight diabetic patients, were enrolled in this study and were categorized into, either control (n = 109) or study group (n = 129), according to 24 hours urinary albumin excretion rate (UAER), from January 2015 to March 2021. The morphologic findings of the kidneys were observed and compared, in both groups, by color doppler ultrasound technique, and blood flow of renal arteries was also measured, at all levels. Fasting plasma glucose (FPG), uric acid, homocysteine, beta-2- microglobulin, cystatin C, hemoglobin A1c (HbA1c) and CRP were also extracted from their laboratory results.
Results: Compared to the control group, the study group had lower intrarenal arterial end-diastolic blood flow velocity (EDV) and higher arterial resistance index (RI) (P ~ < .05). A significant diagnostic value of intrarenal arterial EDV and RI was found for early detection of DN (P ~ < .05). Intrarenal arterial RI and EDV showed positive correlations with UAER, FPG, uric acid, homocysteine, beta-2-microglobulin, cystatin C, HbA1c, and CRP (P ~ < .05).
Conclusion: Color doppler ultrasound markers of renal and intrarenal arteries has a high diagnostic value for DN at its early stage. DOI: 10.52547/ijkd.7246.
期刊介绍:
The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.