{"title":"自杀未遂者血清中神经丝轻链水平升高。","authors":"Mahtab Ramezani, Leila Simani, Mahdiye Golestani Fard, Fatemeh Abbaszadeh, Shahin Shadnia","doi":"10.1515/tnsci-2022-0236","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>A specific biological vulnerability underlies suicidal behavior. Recent findings have suggested a possible role of inflammation and neuroaxonal injury. However, the relationship between inflammation and clinical symptoms in this disorder is still unclear. The objective of this study is applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL) and comparing the results with the healthy control subjects.</p><p><strong>Methods: </strong>In this cross-sectional study patients with suicide attempts were evaluated. The serum concentration of NfL on admission was measured by enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>A total of 50 patients with a suicide attempts and 35 healthy controls were included in the study. The levels of NfL in attempted suicide patients were significantly higher in comparison with healthy controls (40.52 ± 33.54 vs 13.73 ± 5.11, <i>P</i> < 0.001). A significant association between serum levels of NfL and risk factors for suicide was not found.</p><p><strong>Conclusion: </strong>These findings indicate that axonal damage may be an underlying neuropathological component of suicide attempt patients, although no correlation was observed with clinical features. This line of work could lead to new horizons in understanding the neurobiology of suicidal attempts and the development of better management strategies for these patients.</p>","PeriodicalId":23227,"journal":{"name":"Translational Neuroscience","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356285/pdf/","citationCount":"1","resultStr":"{\"title\":\"Increased levels of neurofilament light chain in suicide attempters' serum.\",\"authors\":\"Mahtab Ramezani, Leila Simani, Mahdiye Golestani Fard, Fatemeh Abbaszadeh, Shahin Shadnia\",\"doi\":\"10.1515/tnsci-2022-0236\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>A specific biological vulnerability underlies suicidal behavior. Recent findings have suggested a possible role of inflammation and neuroaxonal injury. However, the relationship between inflammation and clinical symptoms in this disorder is still unclear. The objective of this study is applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL) and comparing the results with the healthy control subjects.</p><p><strong>Methods: </strong>In this cross-sectional study patients with suicide attempts were evaluated. The serum concentration of NfL on admission was measured by enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>A total of 50 patients with a suicide attempts and 35 healthy controls were included in the study. The levels of NfL in attempted suicide patients were significantly higher in comparison with healthy controls (40.52 ± 33.54 vs 13.73 ± 5.11, <i>P</i> < 0.001). A significant association between serum levels of NfL and risk factors for suicide was not found.</p><p><strong>Conclusion: </strong>These findings indicate that axonal damage may be an underlying neuropathological component of suicide attempt patients, although no correlation was observed with clinical features. This line of work could lead to new horizons in understanding the neurobiology of suicidal attempts and the development of better management strategies for these patients.</p>\",\"PeriodicalId\":23227,\"journal\":{\"name\":\"Translational Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2022-08-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356285/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Translational Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1515/tnsci-2022-0236\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1515/tnsci-2022-0236","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 1
摘要
背景:一种特定的生物脆弱性是自杀行为的基础。最近的研究结果表明,炎症和神经轴突损伤可能起作用。然而,炎症与该疾病临床症状之间的关系尚不清楚。本研究的目的是应用神经纤维轻链(NfL)等新的神经轴突完整性血液标志物,并将结果与健康对照进行比较。方法:在本横断面研究中,对有自杀企图的患者进行评估。采用酶联免疫吸附法测定入院时血清NfL浓度。结果:本研究共纳入50例自杀未遂患者和35例健康对照。自杀未遂患者的NfL水平明显高于健康对照组(40.52±33.54 vs 13.73±5.11,P < 0.001)。血清NfL水平与自杀危险因素之间没有显著的关联。结论:这些发现表明轴突损伤可能是自杀未遂患者潜在的神经病理成分,尽管与临床特征没有相关性。这方面的工作可能会为理解自杀企图的神经生物学和为这些患者制定更好的管理策略带来新的视野。
Increased levels of neurofilament light chain in suicide attempters' serum.
Background: A specific biological vulnerability underlies suicidal behavior. Recent findings have suggested a possible role of inflammation and neuroaxonal injury. However, the relationship between inflammation and clinical symptoms in this disorder is still unclear. The objective of this study is applying novel blood markers of neuroaxonal integrity such as neurofilament light chain (NfL) and comparing the results with the healthy control subjects.
Methods: In this cross-sectional study patients with suicide attempts were evaluated. The serum concentration of NfL on admission was measured by enzyme-linked immunosorbent assays.
Results: A total of 50 patients with a suicide attempts and 35 healthy controls were included in the study. The levels of NfL in attempted suicide patients were significantly higher in comparison with healthy controls (40.52 ± 33.54 vs 13.73 ± 5.11, P < 0.001). A significant association between serum levels of NfL and risk factors for suicide was not found.
Conclusion: These findings indicate that axonal damage may be an underlying neuropathological component of suicide attempt patients, although no correlation was observed with clinical features. This line of work could lead to new horizons in understanding the neurobiology of suicidal attempts and the development of better management strategies for these patients.
期刊介绍:
Translational Neuroscience provides a closer interaction between basic and clinical neuroscientists to expand understanding of brain structure, function and disease, and translate this knowledge into clinical applications and novel therapies of nervous system disorders.