NLRP3炎症小体相关动脉粥样硬化中的焦亡。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2022-10-10 eCollection Date: 2022-10-01 DOI:10.15698/cst2022.10.272

Xiang Zeng, Dongling Liu, Xia Huo, Yue Wu, Cuiqing Liu, Qinghua Sun

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引用次数: 5

摘要

焦亡是一种促炎形式的程序性细胞死亡，是对炎症的反应。它参与了以NLRP3炎性体聚集、膜孔形成、细胞肿胀、促炎介质和细胞因子释放为特征的动脉粥样硬化的发病和结局。已知的焦亡分子通路包括caspase-1依赖的典型信号通路和caspase-4/5/11决定的非典型信号通路。探究NLRP3炎症小体、焦亡和动脉粥样硬化之间的关系至关重要，这可能为动脉粥样硬化治疗中针对焦亡的潜在治疗策略提供线索。

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Pyroptosis in NLRP3 inflammasome-related atherosclerosis.

Pyroptosis is a proinflammatory form of programmed cell death in response to inflammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.