血液系统恶性肿瘤的不平衡全臂易位(18;21)(q10;q10)。

Journal of the Association of Genetic Technologists Pub Date : 2020-01-01

Manisha Brahmbhatt Sutariya, Robin Dawn Clark, Suzanne Wilson, Leidy Vargas, Jun Wang, Paul Herrmann

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引用次数: 0

摘要

目的:整个手臂易位在血液恶性肿瘤中相对罕见。有一些关于der(18;21)(q10;q10)的报道。这是一种复发性但罕见的异常。据报道，只有大约11例窝藏der(18;21)(q10;q10)。而合并der(18;21) (q10;q10)和21号染色体的gain则更为罕见，仅报道了3例。既往有AML、AML- m2、aCML诊断。我们报告了第一例ph样b淋巴细胞白血病(B-ALL)的+21和der(18;21)(q10;q10)，导致18p缺失和21q增加。我们解决肿瘤发生和血液学恶性肿瘤涉及(18;21)(q10;q10)的形态学特征，以及文献综述。

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Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies.

Objectives: Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.

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Journal of the Association of Genetic Technologists

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