血液系统恶性肿瘤的不平衡全臂易位(18;21)(q10;q10)。

Journal of the Association of Genetic Technologists Pub Date : 2020-01-01

Manisha Brahmbhatt Sutariya, Robin Dawn Clark, Suzanne Wilson, Leidy Vargas, Jun Wang, Paul Herrmann

{"title":"血液系统恶性肿瘤的不平衡全臂易位(18;21)(q10;q10)。","authors":"Manisha Brahmbhatt Sutariya, Robin Dawn Clark, Suzanne Wilson, Leidy Vargas, Jun Wang, Paul Herrmann","doi":"","DOIUrl":null,"url":null,"abstract":"Objectives: Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.","PeriodicalId":73975,"journal":{"name":"Journal of the Association of Genetic Technologists","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies.\",\"authors\":\"Manisha Brahmbhatt Sutariya, Robin Dawn Clark, Suzanne Wilson, Leidy Vargas, Jun Wang, Paul Herrmann\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.\",\"PeriodicalId\":73975,\"journal\":{\"name\":\"Journal of the Association of Genetic Technologists\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of the Association of Genetic Technologists\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Association of Genetic Technologists","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

目的:整个手臂易位在血液恶性肿瘤中相对罕见。有一些关于der(18;21)(q10;q10)的报道。这是一种复发性但罕见的异常。据报道，只有大约11例窝藏der(18;21)(q10;q10)。而合并der(18;21) (q10;q10)和21号染色体的gain则更为罕见，仅报道了3例。既往有AML、AML- m2、aCML诊断。我们报告了第一例ph样b淋巴细胞白血病(B-ALL)的+21和der(18;21)(q10;q10)，导致18p缺失和21q增加。我们解决肿瘤发生和血液学恶性肿瘤涉及(18;21)(q10;q10)的形态学特征，以及文献综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

微信好友朋友圈 QQ好友复制链接

本刊更多论文

Unbalanced Whole-Arm Translocation der(18;21)(q10;q10) in Hematological Malignancies.

Objectives: Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on der(18;21)(q10;q10). This is a recurrent but rare abnormality. Only about 11 cases harboring der(18;21)(q10;q10) have been reported. However, combined der(18;21) (q10;q10) and gain of chromosome 21 is even rarer, with only three cases reported. The previous cases were with AML, AML-M2, and aCML diagnosis. We report the first case of Ph-like, B-lymphoblastic leukemia (B-ALL) with +21 and der(18;21)(q10;q10) which resulted in loss of 18p and a gain of 21q. We address tumorigenesis and morphological characteristics of hematological malignancies involving der(18;21)(q10;q10), along with a review of the literature.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of the Association of Genetic Technologists

自引率

0.00%

发文量

期刊最新文献

A Case of a Patient with Therapy-related Core Binding Factor (CBF) Acute Myeloid Leukemia (CBF-AML). The Main Genetic-Molecular Aspects of Penile Cancer. The Molecular Breakthroughs in mRNA Biology and Pharmacology that Paved Progress to Develop Effective mRNA Vaccines Against COVID-19. ETV6::RUNX1-like Acute Lymphoblastic Leukemia. Fanconi Anemia, AML, and MDS.