代谢组学在儿童白血病诊断中的应用

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-11-07 DOI:10.1007/s00005-022-00665-6
Agata Kozioł, Małgorzata Pupek
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引用次数: 1

摘要

代谢组学是一门研究和分析活细胞代谢产物的新兴科学领域。本试验方法使用的生物液体有:血液、血浆、血清、脑脊液、唾液和尿液。评估代谢物组成的最流行的方法包括核磁共振光谱和质谱(MS)结合气相色谱- MS或液相色谱- MS。代谢组学在医学的许多领域都有应用。肿瘤细胞中与健康细胞相关的生化过程的可变性是这类研究的起点。目前正在进行的研究的目的主要是寻找快速诊断疾病的生物标志物,评估其进展和治疗效果。代谢组学的发展还可能有助于患者的个体化治疗,根据代谢谱调整药物,从而提高治疗效果,减少副作用,帮助改善患者的生活质量。在这里,我们回顾了代谢组学目前和潜在的应用,重点是它作为儿童白血病的生物标志物方法。图形抽象
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Application of Metabolomics in Childhood Leukemia Diagnostics

Metabolomics is a new field of science dealing with the study and analysis of metabolites formed in living cells. The biological fluids used in this test method are: blood, blood plasma, serum, cerebrospinal fluid, saliva and urine. The most popular methods of assessing the composition of metabolites include nuclear magnetic resonance spectroscopy and mass spectrometry (MS) in combination with gas chromatography–MS or liquid chromatography–MS. Metabolomics is used in many areas of medicine. The variability of biochemical processes in neoplastic cells in relation to healthy cells is the starting point for this type of research. The aim of the research currently being carried out is primarily to find biomarkers for quick diagnosis of the disease, assessment of its advancement and treatment effectiveness. The development of metabolomics may also contribute to the individualization of treatment of patients, adjusting drugs depending on the metabolic profile, and thus may improve the effectiveness of therapy, reduce side effects and help to improve the quality of life of patients. Here, we review the current and potential applications of metabolomics, focusing on its use as a biomarker method for childhood leukemia.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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