Cuihua Wang, Jun Xing, Baoli Zhao, Yahui Wang, Lizhuang Zhang, Yebo Wang, Mingqi Zheng, Gang Liu
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Exercise capacity (peak oxygen consumption (peak VO<sub>2</sub>)) and prognostic markers, such as the anaerobic threshold (AT), minute ventilation/carbon dioxide production (VE/VCO<sub>2</sub>) slope, left ventricular ejection fraction (LVEF), and prognostic value of the predicted VO<sub>2</sub> max per cent (the predicted VO<sub>2</sub> peak (%)) were examined.</p><p><strong>Results: </strong>A total of 15 studies were included comprising 664 patients, 50% of which were male, with an average age of 60.3 ± 13.2 years. For patients with CAD, HIIT significantly improved peak VO<sub>2</sub> values (95% CI 0.7 to 2.11) compared with MICT, but peak VO<sub>2</sub> values in patients with HF did not seem to change. For training lasting less than eight weeks, HIIT significantly improved peak VO<sub>2</sub> values (95% CI 0.70 to 2.10), while HIIT lasting 12 weeks or longer resulted in a modestly increased peak VO<sub>2</sub> value (95% CI 0.31 to 5.31). High-intensity interval training significantly increased the AT when compared with MICT (95% CI 0.50 to 1.48). High-intensity interval training also caused a moderate increase in LVEF (95% CI 0.55 to 5.71) but did not have a significant effect on the VE/VCO<sub>2</sub> slope (95% CI -2.32 to 0.98) or the predicted VO<sub>2</sub> peak (95% CI -2.54 to 9.59) compared with MICT.</p><p><strong>Conclusions: </strong>High-intensity interval training is an effective therapy for improving peak VO<sub>2</sub> values in patients with CAD. High-intensity interval training in the early stage (eight weeks or fewer) is superior to MICT. 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For training lasting less than eight weeks, HIIT significantly improved peak VO<sub>2</sub> values (95% CI 0.70 to 2.10), while HIIT lasting 12 weeks or longer resulted in a modestly increased peak VO<sub>2</sub> value (95% CI 0.31 to 5.31). High-intensity interval training significantly increased the AT when compared with MICT (95% CI 0.50 to 1.48). High-intensity interval training also caused a moderate increase in LVEF (95% CI 0.55 to 5.71) but did not have a significant effect on the VE/VCO<sub>2</sub> slope (95% CI -2.32 to 0.98) or the predicted VO<sub>2</sub> peak (95% CI -2.54 to 9.59) compared with MICT.</p><p><strong>Conclusions: </strong>High-intensity interval training is an effective therapy for improving peak VO<sub>2</sub> values in patients with CAD. High-intensity interval training in the early stage (eight weeks or fewer) is superior to MICT. 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引用次数: 8
摘要
目的:本研究的目的是比较高强度间歇训练(HIIT)与中等强度连续训练(MICT)对冠状动脉疾病(CAD)和心力衰竭(HF)患者运动能力和一些预后指标的影响。方法:本系统评价已在INPLASY网站注册(编号:INPLASY202080112)。我们对2019年9月13日之前的8个文献数据库进行了全面检索。比较52-78岁冠心病或心衰患者HIIT和MICT的试验被纳入。检查运动能力(峰值耗氧量(峰值VO2))和预后指标，如无氧阈值(AT)、分钟通气量/二氧化碳生成(VE/VCO2)斜率、左心室射血分数(LVEF)和预测最大VO2百分比的预后值(预测VO2峰值(%))。结果:共纳入15项研究，664例患者，其中50%为男性，平均年龄60.3±13.2岁。对于CAD患者，与MICT相比，HIIT显著改善了峰值VO2值(95% CI 0.7 - 2.11)，但HF患者的峰值VO2值似乎没有变化。对于持续少于8周的训练，HIIT显著提高峰值VO2值(95% CI 0.70至2.10)，而持续12周或更长时间的HIIT导致峰值VO2值适度增加(95% CI 0.31至5.31)。与MICT相比，高强度间歇训练显著增加了AT (95% CI 0.50 ~ 1.48)。与MICT相比，高强度间歇训练也导致LVEF适度增加(95% CI 0.55至5.71)，但对VE/VCO2斜率(95% CI -2.32至0.98)或预测的VO2峰值(95% CI -2.54至9.59)没有显著影响。结论:高强度间歇训练是提高冠心病患者VO2峰值的有效治疗方法。早期的高强度间歇训练(8周或更短时间)优于间歇训练。最后，HIIT显著改善了CAD和HF患者的预后指标，包括AT和LVEF。
The Effects of High-Intensity Interval Training on Exercise Capacity and Prognosis in Heart Failure and Coronary Artery Disease: A Systematic Review and Meta-Analysis.
Objective: The purpose of this study is to compare the effects of high-intensity interval training (HIIT) versus moderate-intensity continuous training (MICT) on exercise capacity and several prognostic markers in patients with coronary artery disease (CAD) and heart failure (HF).
Methods: This systematic review is registered on the INPLASY website (number: INPLASY202080112). We conducted a comprehensive search in eight databases of literature before September 13, 2019. Trials comparing HIIT and MICT in participants with CAD or HF aged 52-78 years were included. Exercise capacity (peak oxygen consumption (peak VO2)) and prognostic markers, such as the anaerobic threshold (AT), minute ventilation/carbon dioxide production (VE/VCO2) slope, left ventricular ejection fraction (LVEF), and prognostic value of the predicted VO2 max per cent (the predicted VO2 peak (%)) were examined.
Results: A total of 15 studies were included comprising 664 patients, 50% of which were male, with an average age of 60.3 ± 13.2 years. For patients with CAD, HIIT significantly improved peak VO2 values (95% CI 0.7 to 2.11) compared with MICT, but peak VO2 values in patients with HF did not seem to change. For training lasting less than eight weeks, HIIT significantly improved peak VO2 values (95% CI 0.70 to 2.10), while HIIT lasting 12 weeks or longer resulted in a modestly increased peak VO2 value (95% CI 0.31 to 5.31). High-intensity interval training significantly increased the AT when compared with MICT (95% CI 0.50 to 1.48). High-intensity interval training also caused a moderate increase in LVEF (95% CI 0.55 to 5.71) but did not have a significant effect on the VE/VCO2 slope (95% CI -2.32 to 0.98) or the predicted VO2 peak (95% CI -2.54 to 9.59) compared with MICT.
Conclusions: High-intensity interval training is an effective therapy for improving peak VO2 values in patients with CAD. High-intensity interval training in the early stage (eight weeks or fewer) is superior to MICT. Finally, HIIT significantly improved prognostic markers, including the AT and LVEF in patients with CAD and HF.
期刊介绍：
Cardiovascular Therapeutics (formerly Cardiovascular Drug Reviews) is a peer-reviewed, Open Access journal that publishes original research and review articles focusing on cardiovascular and clinical pharmacology, as well as clinical trials of new cardiovascular therapies. Articles on translational research, pharmacogenomics and personalized medicine, device, gene and cell therapies, and pharmacoepidemiology are also encouraged.
Subject areas include (but are by no means limited to):
Acute coronary syndrome
Arrhythmias
Atherosclerosis
Basic cardiac electrophysiology
Cardiac catheterization
Cardiac remodeling
Coagulation and thrombosis
Diabetic cardiovascular disease
Heart failure (systolic HF, HFrEF, diastolic HF, HFpEF)
Hyperlipidemia
Hypertension
Ischemic heart disease
Vascular biology
Ventricular assist devices
Molecular cardio-biology
Myocardial regeneration
Lipoprotein metabolism
Radial artery access
Percutaneous coronary intervention
Transcatheter aortic and mitral valve replacement.
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