Rajdeep Sarma, Anshul Shakya, Arka Karmakar, Surajit Kumar Ghosh, Hans Raj Bhat, Neha Ghimire, Obaidur Rahman
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Due to its chronic manifestations, alternative anti-diarrheal medications must be tested and developed because of the undesirable side effects of currently existing anti-diarrheal drugs.</p><p><strong>Methods: </strong>Several online databases, including Science Direct, PubMed, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to May, 2022.</p><p><strong>Results: </strong>The exhaustive literature study provides a large number of in vivo, in vitro and ex vivo models, which have been used for evaluating the mechanism of the anti-diarrheal effect of drugs in chemically-, pathogen-, disease-induced animal models of diarrhea. The advances and challenges of each model were also addressed in this review.</p><p><strong>Conclusion: </strong>This review encompasses diverse strategies for screening drugs with anti-diarrheal effects and covers a wide range of pathophysiological and molecular mechanisms linked to diarrhea, with a particular emphasis on the challenges of evaluating and predictively validating these experimental models in preclinical studies. This could also help researchers find a new medicine to treat diabetes more effectively and with fewer adverse effects.</p>","PeriodicalId":29871,"journal":{"name":"Current Reviews in Clinical and Experimental Pharmacology","volume":null,"pages":null},"PeriodicalIF":1.3000,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Review Of Preclinical Tools To Validate Anti-Diarrheal Agents.\",\"authors\":\"Rajdeep Sarma, Anshul Shakya, Arka Karmakar, Surajit Kumar Ghosh, Hans Raj Bhat, Neha Ghimire, Obaidur Rahman\",\"doi\":\"10.2174/2772432818666221121113622\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Since their inception, preclinical experimental models have played an important role in investigating and characterizing disease pathogenesis. 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引用次数: 0
摘要
背景:临床前实验模型自诞生以来,在研究和描述疾病发病机制方面发挥了重要作用。这些体内、体外和体外临床前试验还有助于确定靶点、评估潜在的治疗药物和验证治疗方案:腹泻是导致死亡和发病的主要原因,尤其是在发展中国家的儿童中,它是全球范围内医疗保健的巨大挑战。由于腹泻的慢性表现,必须测试和开发替代的止泻药物,因为现有的止泻药物存在不良副作用:文献检索使用了多个在线数据库,包括 Science Direct、PubMed、Web of Science、Google Scholar 和 Scopus。结果:这项详尽的文献研究提供了大量关于腹泻药物的信息:详尽的文献研究提供了大量体内、体外和体外模型,这些模型已被用于在化学、病原体和疾病诱导的腹泻动物模型中评估药物止泻作用的机制。本综述还讨论了每种模型的进展和挑战:本综述包括筛选具有止泻作用的药物的各种策略,涵盖了与腹泻有关的各种病理生理和分子机制,特别强调了在临床前研究中评估和预测验证这些实验模型所面临的挑战。这也有助于研究人员找到更有效、不良反应更少的治疗糖尿病的新药。
A Review Of Preclinical Tools To Validate Anti-Diarrheal Agents.
Background: Since their inception, preclinical experimental models have played an important role in investigating and characterizing disease pathogenesis. These in vivo, ex vivo, and in vitro preclinical tests also aid in identifying targets, evaluating potential therapeutic drugs, and validating treatment protocols.
Introduction: Diarrhea is a leading cause of mortality and morbidity, particularly among children in developing countries, and it represents a huge health-care challenge on a global scale. Due to its chronic manifestations, alternative anti-diarrheal medications must be tested and developed because of the undesirable side effects of currently existing anti-diarrheal drugs.
Methods: Several online databases, including Science Direct, PubMed, Web of Science, Google Scholar and Scopus, were used in the literature search. The datasets were searched for entries of studies up to May, 2022.
Results: The exhaustive literature study provides a large number of in vivo, in vitro and ex vivo models, which have been used for evaluating the mechanism of the anti-diarrheal effect of drugs in chemically-, pathogen-, disease-induced animal models of diarrhea. The advances and challenges of each model were also addressed in this review.
Conclusion: This review encompasses diverse strategies for screening drugs with anti-diarrheal effects and covers a wide range of pathophysiological and molecular mechanisms linked to diarrhea, with a particular emphasis on the challenges of evaluating and predictively validating these experimental models in preclinical studies. This could also help researchers find a new medicine to treat diabetes more effectively and with fewer adverse effects.