解决表型整合的巨大挑战:跨尺度异构。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-08-01 Epub Date: 2022-07-20 DOI:10.1007/s10709-022-00158-6
François Vasseur, Adrianus Johannes Westgeest, Denis Vile, Cyrille Violle
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引用次数: 0

摘要

表型整合是一个与从最低组织层次(即基因)到最高组织层次(即整个生物体的性状)的性状级联关系有关的概念。然而,性状之间的因果联系很难确定。特别是,我们仍然缺乏一个数学框架来模拟表型性状整合所涉及的关系。在这里,我们认为生态学中开发的等距模型为跨尺度的性状关系提供了可检验的数学方程。我们首先说明,在不同组织规模和不同类群的生物学中,异速关系是普遍存在的。然后,我们提出了解释异速关系起源的机理模型。此外,我们强调,最近的研究表明,异速参数确实存在自然变异,这表明遗传变异、选择和进化的作用。因此,我们主张,现在是时候来研究异速关系的遗传决定论,以及更详细地质疑基因组大小在随后的比例关系中的作用了。更广泛地说,理解表型整合的一个可能的--但迄今为止被忽视的--解决方案是研究不同组织层次(细胞、组织、器官、生物体)和不同物种的异倍关系。
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Solving the grand challenge of phenotypic integration: allometry across scales.

Phenotypic integration is a concept related to the cascade of trait relationships from the lowest organizational levels, i.e. genes, to the highest, i.e. whole-organism traits. However, the cause-and-effect linkages between traits are notoriously difficult to determine. In particular, we still lack a mathematical framework to model the relationships involved in the integration of phenotypic traits. Here, we argue that allometric models developed in ecology offer testable mathematical equations of trait relationships across scales. We first show that allometric relationships are pervasive in biology at different organizational scales and in different taxa. We then present mechanistic models that explain the origin of allometric relationships. In addition, we emphasized that recent studies showed that natural variation does exist for allometric parameters, suggesting a role for genetic variability, selection and evolution. Consequently, we advocate that it is time to examine the genetic determinism of allometries, as well as to question in more detail the role of genome size in subsequent scaling relationships. More broadly, a possible-but so far neglected-solution to understand phenotypic integration is to examine allometric relationships at different organizational levels (cell, tissue, organ, organism) and in contrasted species.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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