接受再灌注治疗的急性缺血性脑卒中患者血小板-淋巴细胞比值的预后作用:一项 Meta 分析。

IF 2.6 Q2 CLINICAL NEUROLOGY Journal of Central Nervous System Disease Pub Date : 2022-07-15 eCollection Date: 2022-01-01 DOI:10.1177/11795735221110373
Divyansh Sharma, Sonu M M Bhaskar
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引用次数: 0

摘要

背景:炎症和血栓/止血机制都可能在急性缺血性卒中(AIS)发病机制中发挥作用,考虑这两种机制的生物标志物(如血小板与淋巴细胞比值(PLR))可能具有临床实用性:这项荟萃分析旨在研究 PLR 对接受再灌注疗法(RT)治疗的 AIS 患者的功能预后、早期神经系统变化、出血并发症、死亡率和不良预后的影响:数据来源和方法:从 PubMed/Medline、EMBASE 和 Cochrane 数据库中检索各项研究。此外,还查阅了相关参考文献。使用标准化数据表提取数据,并就入院(RT 前)或延迟(RT 后)PLR 与定义的临床和安全性结果的相关性进行系统综述和荟萃分析。如果存在多个延迟 PLR 时间点,则选择最接近 24 小时的时间点:系统综述确定了 18 项研究(n=4878),其中 14 项研究(n=4413)被纳入荟萃分析。入院时收集的PLR与90天良好功能预后呈显著负相关(SMD=-.32;95% CI = -.58 to -.05;P=.020;z=-2.328),延迟时间点收集的PLR也是如此(SMD=-.43;95% CI = -.54 to -.32;PC结论:就发病率、死亡率和安全性而言,较高的 PLR 与中风后较差的预后相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prognostic Role of the Platelet-Lymphocyte Ratio in Acute Ischemic Stroke Patients Undergoing Reperfusion Therapy: A Meta-Analysis.

Background: Both inflammation and thrombotic/hemostatic mechanisms may play a role in acute ischemic stroke (AIS) pathogenesis, and a biomarker, such as the platelet-to-lymphocyte ratio (PLR), considering both mechanisms may be of clinical utility.

Objectives: This meta-analysis sought to examine the effect of PLR on functional outcomes, early neurological changes, bleeding complications, mortality, and adverse outcomes in AIS patients treated with reperfusion therapy (RT).

Design: Systematic Review and Meta-Analysis.

Data sources and methods: Individual studies were retrieved from the PubMed/Medline, EMBASE and Cochrane databases. References thereof were also consulted. Data were extracted using a standardised data sheet, and systematic reviews and meta-analyses on the association of admission (pre-RT) or delayed (post-RT) PLR with defined clinical and safety outcomes were conducted. In the case of multiple delayed PLR timepoints, the timepoint closest to 24 hours was selected.

Results: Eighteen studies (n=4878) were identified for the systematic review, of which 14 (n=4413) were included in the meta-analyses. PLR collected at admission was significantly negatively associated with 90-day good functional outcomes (SMD=-.32; 95% CI = -.58 to -.05; P=.020; z=-2.328), as was PLR collected at delayed timepoints (SMD=-.43; 95% CI = -.54 to -.32; P<.0001; z=-7.454). PLR at delayed timepoints was also significantly negatively associated with ENI (SMD=-.18; 95% CI = -.29 to -.08; P=.001. Conversely, the study suggested that a higher PLR at delayed timepoints may be associated with radiological bleeding and mortality. The results varied based on the type of RT administered.

Conclusions: A higher PLR is associated with worse outcomes after stroke in terms of morbidity, mortality, and safety outcomes after stroke.

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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
39
审稿时长
8 weeks
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