在雌性大鼠中模拟激素避孕:行为神经生物学研究的框架

IF 6.5 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM Frontiers in Neuroendocrinology Pub Date : 2022-10-01 DOI:10.1016/j.yfrne.2022.101020
Jesse M. Lacasse, Eamonn Gomez-Perales, Wayne G. Brake
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引用次数: 7

摘要

在动物模型中缺乏对激素避孕药(HC)的研究,因此,我们对HC对大脑和行为的影响的理解也是如此。本文综述了HC的药理作用,以及设计雌性大鼠HC模型的方法和最佳实践。我们概述了关于剂量、给药途径、暴露时间/时机和选择对照组的具体方法学考虑。我们还提供了一个框架,概述了HC对行为和神经生物学结果影响的重要分析水平。本文综述的目的是为今后研究HC对雌性大鼠大脑和行为的影响提供基础知识和实验设计的一些基本元素。
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Modeling hormonal contraception in female rats: A framework for studies in behavioral neurobiology

Research on hormonal contraceptives (HC) in animal models is lacking, and as a result, so is our understanding of the impact of HC on the brain and behavior. Here, we provide a review of the pharmacology of HC, as well as the methodology and best practices for designing a model of HC in female rats. We outline specific methodological considerations regarding dosing, route of administration, exposure time/timing, and selecting a control group. We also provide a framework outlining important levels of analysis for thinking about the impact of HC on behavioral and neurobiological outcomes. The purpose of this review is to equip researchers with foundational knowledge, and some basic elements of experimental design for future studies investigating the impact of HC on the brain and behavior of female rats.

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来源期刊
Frontiers in Neuroendocrinology
Frontiers in Neuroendocrinology 医学-内分泌学与代谢
CiteScore
13.30
自引率
6.80%
发文量
62
审稿时长
68 days
期刊介绍: Frontiers in Neuroendocrinology (FIN) publishes a wide range of informative articles including comprehensive reviews, systematic reviews, opinion pieces, and meta-analyses. While the majority of reviews are invited, we also embrace unsolicited reviews and meta-analyses, as well as proposals for thematic special issues, provided they meet our rigorous quality standards. In addition, we encourage authors to submit commentaries that concisely present fresh ideas or offer further analysis to delve deeper into the implications of an article published in our journal.
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