大麻在整个生命周期中的神经认知效应。

IF 2.1 Q3 NEUROSCIENCES Current Behavioral Neuroscience Reports Pub Date : 2021-12-01 Epub Date: 2021-11-15 DOI:10.1007/s40473-021-00244-7

Jarrod M Ellingson, Jesse D Hinckley, J Megan Ross, Joseph P Schacht, L Cinnamon Bidwell, Angela D Bryan, Christian J Hopfer, Paula Riggs, Kent E Hutchison

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引用次数: 2

摘要

综述目的:本综述探讨了大麻在青春期(13-21岁)、成年期(21-65岁)和老年期(65岁以上)的神经认知效应和相关发育因素。最近的研究发现:大麻的使用与较差的神经认知功能密切相关;然而，仔细控制混杂因素的研究通常没有发现任何损害的证据。值得注意的是，内源性大麻素系统可能是大麻使用如何影响神经认知功能的基础，包括青少年时期的脆弱性增加。相比之下，内源性大麻素系统可能是大麻对老年人神经认知保护作用的基础。值得注意的是，老年人最近吸食大麻的人数急剧增加。摘要:由于大麻合法化增加了大麻的可及性、多样性和效力，需要强有力的经验证据来了解其在整个生命周期中的神经认知影响。特别是，需要严格的研究设计来调查大麻的神经认知影响，包括在弱势群体(青少年、老年人)中以及中介(例如，内源性大麻素系统)和调节因素(例如，酒精使用)。

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The Neurocognitive Effects of Cannabis Across the Lifespan.

Purpose of review: This review examines the neurocognitive effects of cannabis and relevant developmental factors across adolescence (age 13-21), adulthood (21-65), and older adulthood (65+).

Recent findings: Cannabis use is robustly associated with poorer neurocognitive functioning; however, studies that carefully control for confounds have often not found any evidence for impairment. Notably, the endocannabinoid system may underly how cannabis use affects neurocognitive functions, including heightened vulnerability during adolescence. In contrast, the endocannabinoid system may underlie protective neurocognitive effects of cannabis in older adults. Notably, older adults have reported sharp increases in recent cannabis use.

Summary: As legalization increases the accessibility, variety, and potency of cannabis, strong empirical evidence is needed to understand its neurocognitive effects across the lifespan. In particular, rigorous study designs are needed to investigate the neurocognitive effects of cannabis, including among vulnerable populations (adolescents, older adults) and mediating (e.g., endocannabinoid system) and moderating factors (e.g., alcohol use).

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来源期刊

Current Behavioral Neuroscience Reports Medicine-Public Health, Environmental and Occupational Health

CiteScore

3.60

自引率

0.00%

发文量

期刊介绍： Under the leadership of Emil Coccaro, Current Behavioral Neuroscience Reports will provide an in-depth review of topics covering personality and impulse control disorders, psychosis, mood and anxiety disorders, genetics and neuroscience, geropsychiatry and cognitive disorders of late life, child and developmental psychiatry, addictions, and neuromodulation.We accomplish this aim by inviting international authorities to contribute review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. By providing clear, insightful balanced contributions, the journal intends to serve those involved in the field of behavioral neuroscience.