吸入空气颗粒物SRM 1648a对DBA/J小鼠轻度胶原性关节炎发展的影响

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2022-07-28 DOI:10.1007/s00005-022-00654-9
Bernadeta Nowak, Grzegorz Majka, Małgorzata Śróttek, Anna Skałkowska, Janusz Marcinkiewicz
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引用次数: 4

摘要

空气污染被认为是类风湿性关节炎(RA)的危险因素之一。胶原诱导关节炎(CIA)是常用的人类类风湿性关节炎小鼠模型。然而,特定颗粒物(PM)成分对RA发病率和严重程度的影响尚不明确。本研究旨在建立一种适合于检测吸入PM致关节炎性的CIA实验模型。用SRM 1648a PM的不同组分吸入DBA1/J小鼠,诱导轻度CIA。评估关节炎的发病率和严重程度,并选择自身免疫和炎症的血清标志物进行测定。临床关节炎观察从加强CII免疫后。在小鼠血清中检测到RA诊断标志物抗环瓜氨酸肽抗体。所有吸入污染物、粗颗粒物、有机含量降低的颗粒物、铁和二氧化硅纳米颗粒都显著增加了CIA的发病率和严重程度。CIA发展的最快进展是由粗PM引起的,并与血清抗cii IgG(主要的关节炎自身抗体)水平升高有关。另一方面,吸入纳米颗粒可提高血清TNFα水平,TNFα是一种主要的促炎关节炎细胞因子。我们推荐这个轻度CIA的实验模型来测试吸入空气污染物导致关节炎恶化的机制。PM加重的关节炎是由炎症介质从发炎的肺部转移到体循环引起的,还是PM转移到血液中直接加剧了关节炎症,还需要进一步的研究来确定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Effect of Inhaled Air Particulate Matter SRM 1648a on the Development of Mild Collagen-Induced Arthritis in DBA/J Mice

Air pollution is considered to be one of a risk factor for rheumatoid arthritis (RA). Collagen-induced arthritis (CIA) is commonly used as a mouse model of human RA. However, the impact of specific particulate matter (PM) components on the incidence and severity of RA has still not been established. The aim of this study was to develop an experimental model of CIA suitable to test arthritogenicity of inhaled PM. A mild form of CIA was induced in DBA1/J mice inhaled with various components of SRM 1648a PM. The incidence and severity of arthritis was assessed, and the selected serum markers of autoimmunity and inflammation were determined. Clinical arthritis was observed from the booster CII immunisation onward. Anti-cyclic citrullinated peptide antibodies, a diagnostic marker of RA, were detected in serum of these mice. All inhaled pollutants, crude PM, PM with reduced organic content, ferric, and silica nanoparticles markedly increased CIA incidence and severity. The fastest progression of CIA development was caused by crude PM and was linked to enhanced serum levels of anti-CII IgG, the prominent arthritogenic autoantibodies. On the other hand, inhaled nanoparticles enhanced serum levels of TNFα, a major proinflammatory arthritogenic cytokine. We recommend this experimental model of mild CIA to test the mechanisms of arthritis exacerbation by inhaled air pollutants. Further studies are necessary to determine whether PM-aggravated arthritis is caused by inflammatory mediators translocated from inflamed lung into systemic circulation or whether PM translocated into the bloodstream directly exacerbate joint inflammation.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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