黑色素细胞毒性化学物质及其毒性机制。

IF 1.6 4区医学 Q4 TOXICOLOGY Toxicological Research Pub Date : 2022-08-22 eCollection Date: 2022-10-01 DOI:10.1007/s43188-022-00144-2

Minjeong Kim, Kyung-Min Lim

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引用次数: 0

摘要

黑素细胞死亡可导致各种与黑素细胞相关的皮肤病，包括白癜风和白皮病。黑色素细胞毒性化学物质是非遗传性黑色素细胞相关疾病的最常见原因之一，该疾病通过细胞凋亡诱导黑色素细胞死亡。众所周知，化妆品、医药、工业和食品添加剂中使用的各种化学物质会导致黑色素细胞死亡，这对消费者和工业工人的健康构成重大风险。这篇综述总结了最近报道的黑色素细胞毒性化学物质及其毒性机制，旨在为更安全的化学物质的开发提供见解。

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Melanocytotoxic chemicals and their toxic mechanisms.

Melanocyte cell death can lead to various melanocyte-related skin diseases including vitiligo and leukoderma. Melanocytotoxic chemicals are one of the most well-known causes of nongenetic melanocyte-related diseases, which induce melanocyte cell death through apoptosis. Various chemicals used in cosmetics, medicine, industry and food additives are known to induce melanocyte cell death, which poses a significant risk to the health of consumers and industrial workers. This review summarizes recently reported melanocytotoxic chemicals and their mechanisms of toxicity in an effort to provide insight into the development of safer chemicals.

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来源期刊

Toxicological Research TOXICOLOGY-

CiteScore

4.20

自引率

4.30%

发文量

期刊介绍： Toxicological Research is the official journal of the Korean Society of Toxicology. The journal covers all areas of Toxicological Research of chemicals, drugs and environmental agents affecting human and animals, which in turn impact public health. The journal’s mission is to disseminate scientific and technical information on diverse areas of toxicological research. Contributions by toxicologists, molecular biologists, geneticists, biochemists, pharmacologists, clinical researchers and epidemiologists with a global view on public health through toxicological research are welcome. Emphasis will be given to articles providing an understanding of the toxicological mechanisms affecting animal, human and public health. In the case of research articles using natural extracts, detailed information with respect to the origin, extraction method, chemical profiles, and characterization of standard compounds to ensure the reproducible pharmacological activity should be provided.