{"title":"钒与糖尿病炎症和氧化应激的生物标志物:动物研究的系统综述。","authors":"Faezeh Ghalichi, Alireza Ostadrahimi, Maryam Saghafi-Asl","doi":"10.34172/hpp.2022.16","DOIUrl":null,"url":null,"abstract":"<p><p><b>Background:</b> Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. <b>Methods:</b> A systematic search was conducted using the PubMed, Scopus, and web of science databases from 1990 to 2021, according to the inclusion and exclusion criteria. The search strategy was based on the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA). Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. <b>Results:</b> In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. A minor risk of bias was reported, based on the SYRCLE's tool. <b>Conclusion:</b> According to the findings, well-designed clinical trials are warranted to assess the long-lasting effects of various vanadium compounds on inflammatory and oxidative stress biomarkers.</p>","PeriodicalId":46588,"journal":{"name":"Health Promotion Perspectives","volume":"12 2","pages":"122-130"},"PeriodicalIF":2.4000,"publicationDate":"2022-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508397/pdf/","citationCount":"4","resultStr":"{\"title\":\"Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies.\",\"authors\":\"Faezeh Ghalichi, Alireza Ostadrahimi, Maryam Saghafi-Asl\",\"doi\":\"10.34172/hpp.2022.16\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Background:</b> Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. <b>Methods:</b> A systematic search was conducted using the PubMed, Scopus, and web of science databases from 1990 to 2021, according to the inclusion and exclusion criteria. The search strategy was based on the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA). Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. <b>Results:</b> In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. A minor risk of bias was reported, based on the SYRCLE's tool. <b>Conclusion:</b> According to the findings, well-designed clinical trials are warranted to assess the long-lasting effects of various vanadium compounds on inflammatory and oxidative stress biomarkers.</p>\",\"PeriodicalId\":46588,\"journal\":{\"name\":\"Health Promotion Perspectives\",\"volume\":\"12 2\",\"pages\":\"122-130\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2022-08-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9508397/pdf/\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Promotion Perspectives\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.34172/hpp.2022.16\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Promotion Perspectives","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/hpp.2022.16","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 4
摘要
背景:氧化应激在高血糖的发生和发展中起着重要作用。钒作为一种具有氧化还原特性的过渡金属,进入氧化还原过程,产生自由基,并分散抗氧化平衡。本动物系统综述旨在评估补充钒对糖尿病诱导动物炎症和氧化应激生物标志物的影响。方法:从1990年到2021年,根据纳入和排除标准,使用PubMed、Scopus和web of science数据库进行系统检索。搜索策略基于动物实验系统综述指南和系统综述首选报告项目(PRISMA)。合格标准是基于动物的研究,评估钒对糖尿病炎症和氧化应激生物标志物的治疗效果。实验动物实验系统评价中心(SYRCLE)工具用于评估纳入研究的方法学质量。结果:在本研究中,评估了341篇文章,其中42篇研究符合入选条件。大多数研究证实了钒对炎症和氧化应激生物标志物的有利特性。根据SYRCLE的工具,报告了轻微的偏倚风险。结论:根据研究结果,有必要进行精心设计的临床试验,以评估各种钒化合物对炎症和氧化应激生物标志物的长期影响。
Vanadium and biomarkers of inflammation and oxidative stress in diabetes: A systematic review of animal studies.
Background: Oxidative stress has a significant role in the commencement and development of hyperglycemia. Vanadium, as a transitional metal with redox properties, enters the redox process, produces free radicals, and distracts the pro-antioxidant balance. The present animal systematic review aimed to assess the effect of vanadium supplementation on inflammation and oxidative stress biomarkers in diabetes-induced animals. Methods: A systematic search was conducted using the PubMed, Scopus, and web of science databases from 1990 to 2021, according to the inclusion and exclusion criteria. The search strategy was based on the guidelines for systematic review of animal experiments and Preferred Reporting Items for Systematic Reviews (PRISMA). Criteria for eligibility were animal-based studies, evaluating the therapeutic effects of vanadium on inflammatory and oxidative stress biomarkers in diabetes. The Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool was used for assessing the methodological quality of included studies. Results: In the present study, 341 articles were evaluated out of which 42 studies were eligible for inclusion. The majority of the studies confirmed the advantageous properties of vanadium on inflammatory and oxidative stress biomarkers. A minor risk of bias was reported, based on the SYRCLE's tool. Conclusion: According to the findings, well-designed clinical trials are warranted to assess the long-lasting effects of various vanadium compounds on inflammatory and oxidative stress biomarkers.