哮喘加重和COVID-19患者鼻病毒合并感染的调查。

IF 2.4 Q3 PHARMACOLOGY & PHARMACY Pharmacy Practice-Granada Pub Date : 2022-04-01 Epub Date: 2022-05-02 DOI:10.18549/PharmPract.2022.2.2665
Abdullah Al-Dulaimi, Ahmad R Alsayed, Mohammed Al Maqbali, Malek Zihlif
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引用次数: 8

摘要

目的:了解约旦哮喘加重患者与COVID-19合并感染人鼻病毒(HRV)的情况。此外,在匹配的基础上确定COVID-19大流行之前和期间急性哮喘发作的频率。方法:前瞻性队列研究的数据包括临床变量。在第一次就诊期间和14天后,采集鼻咽拭子并进行定量聚合酶链反应检测HRV和SARS-CoV-2。结果:175例COVID-19成人病例中有47例(26.9%)被诊断为哮喘。研究参与者中2021年哮喘发作的数量高于2020年(p=0.035)。大多数哮喘患者(61.7%)仅为SARS-CoV-2阳性,38.3%合并感染HRV。与单独感染SARS-CoV-2的样本相比,感染两种病毒的样本的SARS-CoV-2周期阈值较低。结论:我们的研究结果表明,HRV和SARS-CoV-2在哮喘加重期的流行率明显高于稳定型哮喘。因此,在该队列中,HRV和/或SARS-CoV-2感染可能是哮喘加重的辅助因素或促成因素。这是在约旦开展的第一项研究,旨在调查COVID-19哮喘患者的HRV合并感染情况,HRV可能与COVID-19的严重程度较高有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Investigating the human rhinovirus co-infection in patients with asthma exacerbations and COVID-19.

Objective: To investigate the co-infections with human rhinovirus (HRV) among patients with asthma exacerbation and COVID-19 in Jordan. Also, to determine the frequency of acute asthma exacerbation before and during the COVID-19 pandemic on a matched basis.

Methods: The data of this prospective cohort research consisted of clinical variables. During the first visit, and after 14-days, nasopharyngeal swabs were taken and the quantitative polymerase chain reaction was performed for HRV and SARS-CoV-2 detection.

Results: Forty-seven out of 175 (26.9%) COVID-19 adult cases have been diagnosed with asthma. The number of asthma exacerbations among the study participants was higher during 2021 than in 2020 (p=0.035). Most of the included asthmatic participants (61.7%) were only positive for SARS-CoV-2 and 38.3% were co-infected with HRV. The SARS-CoV-2 cycle threshold value was lower in samples infected with both viruses compared to samples infected with SARS-CoV-2 alone, p<0.005.

Conclusion: Our findings indicate that HRV and SARS-CoV-2 were significantly more prevalent in asthma exacerbations than stable asthma. Thus, HRV and/or SARS-CoV-2 infections were potentially cofactors or contributors to the asthma exacerbation in this cohort. This is the first study, in Jordan, to investigate the HRV co-infection in COVID-19 asthmatic patients and HRV could be related with a higher severity of COVID-19.

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来源期刊
Pharmacy Practice-Granada
Pharmacy Practice-Granada PHARMACOLOGY & PHARMACY-
CiteScore
3.90
自引率
4.00%
发文量
113
审稿时长
20 weeks
期刊介绍: Pharmacy Practice is a free full-text peer-reviewed journal with a scope on pharmacy practice. Pharmacy Practice is published quarterly. Pharmacy Practice does not charge and will never charge any publication fee or article processing charge (APC) to the authors. The current and future absence of any article processing charges (APCs) is signed in the MoU with the Center for Pharmacy Practice Innovation (CPPI) at Virginia Commonwealth University (VCU) School of Pharmacy. Pharmacy Practice is the consequence of the efforts of a number of colleagues from different Universities who belief in collaborative publishing: no one pays, no one receives. Although focusing on the practice of pharmacy, Pharmacy Practice covers a wide range of pharmacy activities, among them and not being comprehensive, clinical pharmacy, pharmaceutical care, social pharmacy, pharmacy education, process and outcome research, health promotion and education, health informatics, pharmacoepidemiology, etc.
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