Onyekachi Anukam, Natalia Blanco, Jibreel Jumare, Julia Lo, Ezra Babatunde, Solomon Odafe, Dennis Onotu, Uzoma Ene, Johnson Fagbamigbe, Deborah Carpenter, Emilia D Rivadeneira, Austin I Omoigberale, Manhattan Charurat, Mahesh Swaminathan, Kristen A Stafford
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引用次数: 0
摘要
背景:本论文旨在研究艾滋病毒阳性儿童和青少年的治疗结果。方法:我们回顾性分析了尼日利亚30个州和联邦首都直辖区参与地点的0-19岁开始抗逆转录病毒治疗(2007年10月至2016年9月)患者样本的数据。结果:在随访结束时存活的4006例患者中，138例(3.4%)为LTFU。青少年发生LTFU的风险明显高于3-5岁儿童(HR 2.47 [95% CI 1.40-4.34])。晚期疾病患者发生LTFU的风险明显更高(IV期HR, 3.66 [95% CI: 2.00-6.68])。平均而言，67.3%的患者达到了最佳ART补充依从性。结论:我们的研究结果表明，将重点放在预防和管理晚期疾病和干预措施上，支持青少年转到成人护理是有必要的。
Outcomes of HIV Positive Children and Adolescents Initiated on Antiretroviral Treatment in Nigeria (2007-2016).
Background: This manuscript aimed to examine treatment outcomes of HIV-positive children and adolescents. Methods: We retrospectively analyzed data of a sample of patients aged 0-19 years who initiated ART (October 2007-September 2016) in participating sites in 30 states and the Federal Capital Territory in Nigeria. Results: Among 4006 patients alive at the end of the follow up period, 138 (3.4%) were LTFU. Adolescents had a significantly higher risk of being LTFU than children aged 3-5 years (HR 2.47 [95% CI 1.40-4.34]). Patients with advanced disease had a significantly higher risk of being LTFU (Stage IV HR, 3.66 [95% CI: 2.00-6.68]). On average, optimal ART refill adherence was met by 67.3% of patients. Conclusion: Our findings suggest that focusing on preventing and managing advanced disease and interventions supporting adolescents when transferring to adult care is warranted.
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