COVID-19感染前后甲状腺功能的研究进展

TouchREVIEWS in endocrinology Pub Date : 2022-06-01 Epub Date: 2022-06-13 DOI:10.17925/EE.2022.18.1.58
Sabri Artun Çabuk, Ayşe Zeynep Cevher, Yaşar Küçükardalı
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引用次数: 5

摘要

严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染可通过肺部和全身炎症导致多器官功能障碍。感染还通过病毒的细胞病理学作用直接影响甲状腺,或通过细胞因子、补体系统和凝血机制间接影响甲状腺。甲状腺通过基因组和非基因组途径调节先天和适应性免疫系统。在感染SARS-CoV-2期间或之后,可能引发Graves病和亚急性甲状腺炎,导致甲状腺功能亢进;或者,病毒对垂体的影响。下丘脑轴可能引起中枢性甲状腺功能减退。2019冠状病毒病(COVID-19)的严重病例可能出现缺氧,这需要使用地塞米松。这可以降低3,5,3'-三碘甲状腺原氨酸的基础血清浓度。COVID-19患者使用地塞米松时应监测甲状腺功能。本文就SARS-CoV-2对甲状腺及功能的直接和间接影响作一综述。
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Thyroid Function During and After COVID-19 Infection: A Review.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to multiorgan dysfunction through pulmonary and systemic inflammation. Infection also affects the thyroid gland directly via cytopathological effects of the virus or indirectly through cytokines, complement systems and coagulation mechanisms. The thyroid gland regulates innate and adaptive immune systems by genomic and nongenomic pathways. During or after SARS-CoV-2 infection, Graves' disease and subacute thyroiditis might be triggered resulting in hyperthyroidism; alternatively, the effect of the virus on the hypophyseal.hypothalamic axis might cause central hypothyroidism. Severe cases of coronavirus disease 2019 (COVID-19) can present with hypoxia, which requires the use of dexamethasone. This can depress basal serum concentrations of 3,5,3'-triiodothyronine. Thyroid function should be monitored when using dexamethasone in patients with COVID-19. This article briefly reviews the direct and indirect effects of SARS-CoV-2 on the thyroid gland and function.

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