多参数MRI序列测量前列腺癌指数病变体积的比较研究。

IF 2 4区 医学 Q4 Medicine Journal of the Belgian Society of Radiology Pub Date : 2022-11-10 eCollection Date: 2022-01-01 DOI:10.5334/jbsr.2832
Omer Bagcilar, Deniz Alis, Mustafa Seker, Servet Erdemli, Umut Karaarslan, Aylin Kus, Cavit Kayhan, Yesim Saglican, Ali Kural, Ercan Karaarslan
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引用次数: 0

摘要

目的:比较个体多参数前列腺MRI (mpMRI)序列——t2w、弥散加权成像(DWI)、表观弥散系数(ADC)和动态对比增强(DCE)——以全载病理为基础评估前列腺癌(PCa)指数病变体积的有效性;评估直肠内线圈(ERC)对测量结果的影响。材料和方法:我们回顾性地招募了72例PCa患者,他们接受了3T mpMRI检查,伴有ERC (n = 39)或没有ERC (n = 33)。病理学家用平面测量法(whole-mountvol)在全载病理上绘制病变指数边界。放射科医生在每个mpMRI序列上绘制了索引病变的边界- t2wvol, DWIvol, ADCvol和DCEvol。此外,我们计算了每个患者的最大指数病变体积(maxMRIvol)。研究了mpMRI与全载病理在测量指数病变体积和ERC影响方面的相关性和差异。结果:T2Wvol、DWIvol、ADCvol、DCEvol和maxMRIvol的中位值分别为0.68 cm3、0.97 cm3、0.98 cm3、0.82 cm3和1.13 cm3。全山与mpMRI序列之间存在良好的正相关关系。然而,所有mpmri导出的体积都低估了中位全体积1.97 cm3 (P≤0.001),T2Wvol的体积低估最大,而DWIvol和ADCvol的体积低估最小。在有无ERC的情况下,maxMRIvol相对指数病变体积的平均低估值分别为39.16%±32.58%和7.65%±51.91% (P = 0.002)。结论:与全载病理相比,T2Wvol、DWIvol、ADCvol、DCEvol和maxMRIvol严重低估了PCa指数病变体积,其中T2Wvol的低估体积最大。此外,使用ERC加剧了对体积的低估。
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A Comparative Study of Multiparametric MRI Sequences in Measuring Prostate Cancer Index Lesion Volume.

Objectives: To compare the effectiveness of individual multiparametric prostate MRI (mpMRI) sequences-T2W, diffusion-weighted imaging (DWI) and apparent diffusion coefficient (ADC), and dynamic contrast-enhanced (DCE)-in assessing prostate cancer (PCa) index lesion volume using whole-mount pathology as the ground-truth; to assess the impact of an endorectal coil (ERC) on the measurements.

Materials and methods: We retrospectively enrolled 72 PCa patients who underwent 3T mpMRI with (n = 39) or without (n = 33) an ERC. A pathologist drew the index lesion borders on whole-mount pathology using planimetry (whole-mountvol). A radiologist drew the borders of the index lesion on each mpMRI sequence-T2Wvol, DWIvol, ADCvol, and DCEvol. Additionally, we calculated the maximum index lesion volume for each patient (maxMRIvol). The correlation and differences between mpMRI and whole-mount pathology in measuring the index lesion volume and the impact of an ERC were investigated.

Results: The median T2Wvol, DWIvol, ADCvol, DCEvol, and maxMRIvol were 0.68 cm3, 0.97 cm3, 0.98 cm3, 0.82 cm3, and 1.13 cm3. There were good positive correlations between whole-mountvol and mpMRI sequences. However, all mpMRI-derived volumes underestimated the median whole-mountvol volume of 1.97 cm3 (P ≤ 0.001), with T2Wvol having the largest volumetric underestimation while DWIvol and ADCvol having the smallest. The mean relative index lesion volume underestimations of maxMRIvol were 39.16% ± 32.58% and 7.65% ± 51.91% with and without an ERC (P = 0.002).

Conclusion: T2Wvol, DWIvol, ADCvol, DCEvol, and maxMRIvol substantially underestimate PCa index lesion volume compared with whole-mount pathology, with T2Wvol having the largest volume underestimation. Additionally, using an ERC exacerbates the volume underestimation.

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来源期刊
Journal of the Belgian Society of Radiology
Journal of the Belgian Society of Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
0.60
自引率
5.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The purpose of the Journal of the Belgian Society of Radiology is the publication of articles dealing with diagnostic and interventional radiology, related imaging techniques, allied sciences, and continuing education.
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