{"title":"β -肾上腺素能阻断药物作用下乌阿拜对兔左心房的肌力作用。","authors":"J V LEVY, V RICHARDS","doi":"10.3181/00379727-119-30158","DOIUrl":null,"url":null,"abstract":"Summary The positive inotropic effects of ouabain on electrically driven rabbit left atrial preparations was studied in the presence of 3 drugs known to be potent and specific beta-adrenergic receptor antagonists (pronethalol, propranolol and MJ-1999). Ouabain alone (6.9 × 10-7 M) produced a highly significant increase in contraction force compared to untreated controls. Pronethalol (3.76 × 10-6 M) and propranolol (1.35 × 10-6 M) were found to produce significant decreases in contraction force. The methanesulfonanilide substituted isopropylphenylethylamine (MJ-1999) had no significant effects on contraction force in a concentration of 1.3 × 10-5 M. Administering ouabain after pretreatment with and in the presence of either pronethalol, propranolol, or MJ-1999 failed to modify significantly the normal positive inotropic effect of the glycoside. Therefore, no evidence was found to indicate that beta-adrenergic receptor blockade could prevent the positive inotropic effect of ouabain on isolated rabbit left atria.","PeriodicalId":20675,"journal":{"name":"Proceedings of the Society for Experimental Biology and Medicine","volume":" ","pages":"278-81"},"PeriodicalIF":0.0000,"publicationDate":"1965-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3181/00379727-119-30158","citationCount":"18","resultStr":"{\"title\":\"INOTROPIC EFFECTS OF OUABAIN ON RABBIT LEFT ATRIA IN PRESENCE OF BETA-ADRENERGIC BLOCKING DRUGS.\",\"authors\":\"J V LEVY, V RICHARDS\",\"doi\":\"10.3181/00379727-119-30158\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Summary The positive inotropic effects of ouabain on electrically driven rabbit left atrial preparations was studied in the presence of 3 drugs known to be potent and specific beta-adrenergic receptor antagonists (pronethalol, propranolol and MJ-1999). Ouabain alone (6.9 × 10-7 M) produced a highly significant increase in contraction force compared to untreated controls. Pronethalol (3.76 × 10-6 M) and propranolol (1.35 × 10-6 M) were found to produce significant decreases in contraction force. The methanesulfonanilide substituted isopropylphenylethylamine (MJ-1999) had no significant effects on contraction force in a concentration of 1.3 × 10-5 M. Administering ouabain after pretreatment with and in the presence of either pronethalol, propranolol, or MJ-1999 failed to modify significantly the normal positive inotropic effect of the glycoside. Therefore, no evidence was found to indicate that beta-adrenergic receptor blockade could prevent the positive inotropic effect of ouabain on isolated rabbit left atria.\",\"PeriodicalId\":20675,\"journal\":{\"name\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"volume\":\" \",\"pages\":\"278-81\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1965-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3181/00379727-119-30158\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Society for Experimental Biology and Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3181/00379727-119-30158\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Society for Experimental Biology and Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3181/00379727-119-30158","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
INOTROPIC EFFECTS OF OUABAIN ON RABBIT LEFT ATRIA IN PRESENCE OF BETA-ADRENERGIC BLOCKING DRUGS.
Summary The positive inotropic effects of ouabain on electrically driven rabbit left atrial preparations was studied in the presence of 3 drugs known to be potent and specific beta-adrenergic receptor antagonists (pronethalol, propranolol and MJ-1999). Ouabain alone (6.9 × 10-7 M) produced a highly significant increase in contraction force compared to untreated controls. Pronethalol (3.76 × 10-6 M) and propranolol (1.35 × 10-6 M) were found to produce significant decreases in contraction force. The methanesulfonanilide substituted isopropylphenylethylamine (MJ-1999) had no significant effects on contraction force in a concentration of 1.3 × 10-5 M. Administering ouabain after pretreatment with and in the presence of either pronethalol, propranolol, or MJ-1999 failed to modify significantly the normal positive inotropic effect of the glycoside. Therefore, no evidence was found to indicate that beta-adrenergic receptor blockade could prevent the positive inotropic effect of ouabain on isolated rabbit left atria.