杯芳烃:超分子化学在癌症治疗中的应用进展

IF 2.3 4区 化学 Q2 Agricultural and Biological Sciences Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2022-03-02 DOI:10.1007/s10847-022-01134-5
Aysen Isik, Mehmet Oguz, Ahmet Kocak, Mustafa Yilmaz
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引用次数: 2

摘要

癌症是世界范围内导致死亡的主要原因之一,目前使用的抗癌药物的有限成功是寻找具有抗癌潜力的新化合物的动力。杯芳烃构成了一类令人着迷的大环,在超分子化学中有着广泛的生物应用。特别是近年来,各种杯芳烃衍生物的抗癌活性被许多研究者报道。本文的目的是寻找相对简单、高效的合成方法来制备含有多种药理基团的大环化合物,为癌症研究提供新的有效的抗癌材料,并探讨杯芳烃基超分子在癌症研究中的应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Calixarenes: recent progress in supramolecular chemistry for application in cancer therapy

Cancer is one of the leading causes of death worldwide, and the limited success of currently used anticancer drugs is a driving force for the search for new compounds with anticancer potential. Calixarenes make up a fascinating class of macrocycles that find a wide range of biological applications in supramolecular chemistry. Especially in recent years, the anticancer activity of various calixarene derivatives has been reported by many researchers. The aim of this review article is to find relatively simple, efficient, and synthetic methods for the preparation of macrocyclic compounds containing various pharmacophoric groups to produce new and effective anticancer materials in cancer research and to investigate the usability of calixarene-based supramolecular in cancer research.

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来源期刊
CiteScore
3.30
自引率
8.70%
发文量
0
审稿时长
3-8 weeks
期刊介绍: The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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