Aysen Isik, Mehmet Oguz, Ahmet Kocak, Mustafa Yilmaz
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Calixarenes: recent progress in supramolecular chemistry for application in cancer therapy
Cancer is one of the leading causes of death worldwide, and the limited success of currently used anticancer drugs is a driving force for the search for new compounds with anticancer potential. Calixarenes make up a fascinating class of macrocycles that find a wide range of biological applications in supramolecular chemistry. Especially in recent years, the anticancer activity of various calixarene derivatives has been reported by many researchers. The aim of this review article is to find relatively simple, efficient, and synthetic methods for the preparation of macrocyclic compounds containing various pharmacophoric groups to produce new and effective anticancer materials in cancer research and to investigate the usability of calixarene-based supramolecular in cancer research.
期刊介绍：
The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites.
The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.
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