百合花颜色变异的分子遗传基础。

Lisete Galego, Jorge Almeida
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引用次数: 13

摘要

为了鉴定可能用于诱变的转座子,我们研究了模式种Antirrhinum majus的近亲Linaria花颜色变异的遗传分子基础。我们表明,这种变异是由于编码二氢黄酮醇-4还原酶的基因的不稳定突变等位基因,这是花青素生物合成所需的酶之一。该等位基因携带一个属于CACTA家族的转座子(Tl1,转座子Linaria 1)的插入,该转座子阻止其表达,从而赋予象牙色的花朵表型。偶尔在表皮细胞分裂过程中,Tl1被切除以产生象牙色背景上的红色组织克隆斑块,以及在产生配子的细胞中,Tl1被切除以产生可逆等位基因,从而获得全彩色表型。这一发现可能为Linaria的靶向转座子诱变开辟了道路,并因此在比较遗传学研究中使用该属。
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Molecular genetic basis of flower colour variegation in Linaria.

To identify transposons that may be of use for mutagenesis we investigated the genetic molecular basis of a case of flower colour variegation in Linaria, a close relative of the model species Antirrhinum majus. We show that this variegation is attributable to an unstable mutant allele of the gene encoding dihydroflavonol-4-reductase, one of the enzymes required for anthocyanin biosynthesis. This allele carries an insertion of a transposon belonging to the CACTA family (Tl1, Transposon Linaria 1) which blocks its expression thus conferring an ivory flower colour phenotype. Tl1 is occasionally excised in dividing epidermal cells to produce clonal patches of red tissue on the ivory background, and in cells giving rise to gametes to generate reversion alleles conferring a fully coloured phenotype. This finding may open the way for targeted transposon-mutagenesis in Linaria, and hence for using this genus in comparative genetic studies.

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