Xiao Han, Kun Liu, Anran Fu, Zongchen Ma, Zhe Wang, Xiaolei Li, Xuli Tang, Dahai Zhang* and Guoqiang Li*,
{"title":"具有抗炎和护肝活性的软珊瑚异xenia ghardaqensis的异内酯和异内酰胺类化合物A–M，黄萎烷二萜","authors":"Xiao Han, Kun Liu, Anran Fu, Zongchen Ma, Zhe Wang, Xiaolei Li, Xuli Tang, Dahai Zhang* and Guoqiang Li*, ","doi":"10.1021/acs.jnatprod.3c00330","DOIUrl":null,"url":null,"abstract":"<p >Fourteen new verticillane diterpenoids, heterolactone (<b>1</b>) and heterolactams A–M (<b>2</b>–<b>14</b>), were isolated from the soft coral <i>Heteroxenia ghardaqensis</i>. They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds <b>5</b>, <b>8</b>, and <b>9</b> showed anti-inflammatory activities, and <b>2</b>, <b>8</b>, and <b>12</b> displayed hepatoprotective activities in zebrafish assays.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"86 9","pages":"2131–2138"},"PeriodicalIF":3.3000,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Heterolactone and Heterolactams A–M, Verticillane Diterpenoids with Anti-Inflammatory and Hepatoprotective Activities from the Soft Coral Heteroxenia ghardaqensis\",\"authors\":\"Xiao Han, Kun Liu, Anran Fu, Zongchen Ma, Zhe Wang, Xiaolei Li, Xuli Tang, Dahai Zhang* and Guoqiang Li*, \",\"doi\":\"10.1021/acs.jnatprod.3c00330\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Fourteen new verticillane diterpenoids, heterolactone (<b>1</b>) and heterolactams A–M (<b>2</b>–<b>14</b>), were isolated from the soft coral <i>Heteroxenia ghardaqensis</i>. They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds <b>5</b>, <b>8</b>, and <b>9</b> showed anti-inflammatory activities, and <b>2</b>, <b>8</b>, and <b>12</b> displayed hepatoprotective activities in zebrafish assays.</p>\",\"PeriodicalId\":47,\"journal\":{\"name\":\"Journal of Natural Products \",\"volume\":\"86 9\",\"pages\":\"2131–2138\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2023-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Natural Products \",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00330\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Natural Products ","FirstCategoryId":"99","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acs.jnatprod.3c00330","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Heterolactone and Heterolactams A–M, Verticillane Diterpenoids with Anti-Inflammatory and Hepatoprotective Activities from the Soft Coral Heteroxenia ghardaqensis
Fourteen new verticillane diterpenoids, heterolactone (1) and heterolactams A–M (2–14), were isolated from the soft coral Heteroxenia ghardaqensis. They structurally share the same 6/12 bicyclic carbon skeleton that is not commonly encountered in marine organisms. The structures, including the absolute configurations, were determined by extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, calculated ECD spectra, and DP4+ probability analyses. Compounds 5, 8, and 9 showed anti-inflammatory activities, and 2, 8, and 12 displayed hepatoprotective activities in zebrafish assays.
期刊介绍：
The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
When new compounds are reported, manuscripts describing their biological activity are much preferred.
Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.
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