氯胺酮:抑郁症的治疗机制及其相关性。

IF 15.1 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Annual review of medicine Pub Date : 2024-01-29 Epub Date: 2023-09-20 DOI:10.1146/annurev-med-051322-120608
Ji-Woon Kim, Kanzo Suzuki, Ege T Kavalali, Lisa M Monteggia
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引用次数: 0

摘要

重性抑郁障碍(MDD)是世界上自杀的主要原因。以单胺为基础的抗抑郁药物是治疗这种精神障碍的主要途径,尽管一些患者的反应延迟和疗效不完全突出了改进治疗方法的必要性。在过去的二十年里,氯胺酮在MDD对传统抗抑郁药物没有反应的患者中表现出快速起效和持续(长达几天)的抗抑郁作用。最近的临床前研究已经开始阐明氯胺酮抗抑郁特性的潜在机制。在此,我们描述并比较了最近的临床和临床前发现,为氯胺酮抗抑郁作用的相关机制提供了一个广阔的视角。《医学年度评论》第75卷预计最终在线出版日期为2024年1月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
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Ketamine: Mechanisms and Relevance to Treatment of Depression.

Major depressive disorder (MDD) is a leading cause of suicide in the world. Monoamine-based antidepressant drugs are a primary line of treatment for this mental disorder, although the delayed response and incomplete efficacy in some patients highlight the need for improved therapeutic approaches. Over the past two decades, ketamine has shown rapid onset with sustained (up to several days) antidepressant effects in patients whose MDD has not responded to conventional antidepressant drugs. Recent preclinical studies have started to elucidate the underlying mechanisms of ketamine's antidepressant properties. Herein, we describe and compare recent clinical and preclinical findings to provide a broad perspective of the relevant mechanisms for the antidepressant action of ketamine.

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来源期刊
Annual review of medicine
Annual review of medicine 医学-医学:内科
CiteScore
24.90
自引率
0.00%
发文量
58
期刊介绍: The Annual Review of Medicine, which has been published since 1950, focuses on important advancements in diverse areas of medicine. These include AIDS/HIV, cardiology, clinical pharmacology, dermatology, endocrinology/metabolism, gastroenterology, genetics, immunology, infectious disease, neurology, oncology/hematology, pediatrics, psychiatry, pulmonology, reproductive medicine, and surgery. The journal's current volume has transitioned from a gated access model to an open access model through the Annual Reviews' Subscribe to Open program. All articles published in the journal are now available under a CC BY license.
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