尾黑质的光遗传学抑制使行为对不确定的威胁和安全性的反应增强。

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-05 DOI:10.1037/bne0000568
Kristina M Wright, Shannon Cieslewski, Amanda Chu, Michael A McDannald
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引用次数: 0

摘要

防御反应在接近当前威胁时是自适应的,但在超过当前威胁时则是不适应的。在这里,我们询问了黑质,一个一直与奖励有关的区域,是否有必要在巴甫洛夫恐惧歧视中表现出适当水平的防御反应。大鼠接受用盐视紫红质或对照荧光团对尾黑质的双侧转导和双侧套圈植入。然后,大鼠对预测独特足部电击概率的线索进行行为辨别(危险,p=1;不确定性,p=.25;安全性,p=0)。提示提示期间的绿光照射(532nm)通过抑制对超出控制水平的不确定性和安全性的奖励寻求来测量卤视紫红质大鼠的防御反应。提示提示外的绿光照射对卤视紫红质或对照大鼠的反应没有影响。研究结果表明,尾侧黑质线索活动对于抑制对非威胁性和不确定威胁线索的防御反应是必要的。(PsycInfo数据库记录(c)2023 APA,保留所有权利)。
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Optogenetic inhibition of the caudal substantia nigra inflates behavioral responding to uncertain threat and safety.

Defensive responding is adaptive when it approximates the current threat but maladaptive when it exceeds the current threat. Here we asked if the substantia nigra, a region consistently implicated in reward, is necessary to show appropriate levels of defensive responding in Pavlovian fear discrimination. Rats received bilateral transduction of the caudal substantia nigra with halorhodopsin or a control fluorophore and bilateral ferrule implants. Rats then behaviorally discriminated cues predicting unique foot shock probabilities (danger, p = 1; uncertainty, p = .25; and safety, p = 0). Green-light illumination (532 nm) during cue presentation inflated defensive responding of halorhodopsin rats-measured by suppression of reward seeking-to uncertainty and safety beyond control levels. Green-light illumination outside of cue presentation had no impact on halorhodopsin or control rat responding. The results reveal caudal substantia nigra cue activity is necessary to inhibit defensive responding to nonthreatening and uncertain threat cues. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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