【神经再生相关蛋白在皮肤纤维化中的作用机制研究进展】。

Q3 Medicine Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Pub Date : 2023-05-20 DOI:10.3760/cma.j.cn501225-20220701-00278

W Chen, G C Xu, Z L Huang, L Chen, K Y Nie

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引用次数: 0

摘要

皮肤损伤后的愈合过程是各种细胞、细胞因子和细胞外基质相互作用的动态过程。纤维化是皮肤损伤修复的主要途径之一。纤维化的过程涉及许多因素的调节。研究表明，神经再生相关蛋白（NREP）在皮肤组织和器官的纤维化中起着关键作用。本文从皮肤纤维化的机制出发，探讨了NREP三级结构的构建，总结了NREP和皮肤中不同细胞对皮肤纤维化的影响，以及NREP在皮肤纤维化机制方面的研究进展，为治疗皮肤纤维化疾病提供了新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[Research advances on the mechanism of nerve regeneration-related protein in skin fibrosis].

The healing process after skin injury is a dynamic process of interaction between various cells, cytokines, and extracellular matrix. Fibrosis is one of the main ways of skin injury repair. The process of fibrosis involves the regulation of many factors. Studies have shown that nerve regeneration-related protein (NREP) plays a key role in the fibrosis of skin tissue and organs. Based on the mechanism of skin fibrosis, this paper discusses the construction of tertiary structure of NREP, summarizes the effects of NREP and different cells in the skin on skin fibrosis and the research progress of mechanism of NREP in skin fibrosis, thus providing new ideas for the treatment of skin fibrosis diseases.

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来源期刊

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns Medicine-Medicine (all)

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8511

期刊介绍： The Chinese Journal of Burns is the most authoritative one in academic circles of burn medicine in China. It adheres to the principle of combining theory with practice and integrating popularization with progress and reflects advancements in clinical and scientific research in the field of burn in China. The readers of the journal include burn and plastic clinicians, and researchers focusing on burn area. The burn refers to many correlative medicine including pathophysiology, pathology, immunology, microbiology, biochemistry, cell biology, molecular biology, and bioengineering, etc. Shock, infection, internal organ injury, electrolytes and acid-base, wound repair and reconstruction, rehabilitation, all of which are also the basic problems of surgery.