槲皮素和达沙替尼,这两种治疗年龄相关心血管疾病的强效解毒剂。

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY Biogerontology Pub Date : 2024-02-01 Epub Date: 2023-09-25 DOI:10.1007/s10522-023-10068-5
Mario Nieto, Mina Konigsberg, Alejandro Silva-Palacios
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引用次数: 0

摘要

细胞衰老是多种年龄相关疾病发展和进展的特征。衰老细胞在心脏中的积累导致了各种与年龄相关的疾病。一些被称为senolytics的化合物已经被设计用来消除组织中的这些细胞。近年来,senolytics的使用和研究有所增加,为寻找心血管疾病(CVD)治疗的可获得和安全的疗法提供了一个很有前途的领域。这篇小型综述讨论了衰老心脏的变化和衰老细胞参与心血管疾病,以及使用senolytics预防心肌损伤的进展,主要是达沙替尼和槲皮素的作用。特别是,讨论了衰老心脏的senolytics疗法的机制和生理效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Quercetin and dasatinib, two powerful senolytics in age-related cardiovascular disease.

Cellular senescence is characteristic of the development and progression of multiple age-associated diseases. Accumulation of senescent cells in the heart contributes to various age-related pathologies. Several compounds called senolytics have been designed to eliminate these cells within the tissues. In recent years, the use and study of senolytics increased, representing a promising field for finding accessible and safe therapies for cardiovascular disease (CVD) treatment. This mini-review discusses the changes in the aging heart and the participation of senescent cells in CVD, as well as the use of senolytics to prevent the progression of myocardial damage, mainly the effect of dasatinib and quercetin. In particular, the mechanisms and physiological effects of senolytics therapies in the aged heart are discussed.

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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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