一项基于人群的横断面研究中的新型计算IgE聚类:绘制过敏负担图。

IF 4.6 2区 医学 Q2 ALLERGY Clinical and Translational Allergy Pub Date : 2023-09-05 DOI:10.1002/clt2.12292
Rebecca Czolk, Maria Ruiz-Castell, Oliver Hunewald, Naphisabet Wanniang, Gwenaëlle Le Coroller, Christiane Hilger, Michel Vaillant, Guy Fagherazzi, Françoise Morel-Codreanu, Markus Ollert, Annette Kuehn
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引用次数: 0

摘要

背景:尽管过敏的患病率在增加,但基于人群的数据仍然很少。作为慢性炎症信息的读数,需要新的方法来整合个体生物学测量和生活方式参数,以减轻社会过敏负担的后果和成本。方法:在具有代表性的横断面欧洲健康检查调查中,从1462名卢森堡成年人中收集了480.000多个数据点,涵盖健康和生活方式报告。基于无监督聚类的深层IgE图谱与健康调查数据相关。结果:42.6%的参与者报告了医生诊断的过敏,44%的参与者对至少一种过敏原或提取物呈IgE阳性。主要致敏来源是树花粉,其次是草花粉和螨虫(分别占致敏参与者的52.4%、51.8%和40.3%),表明季节性和常年性负担。最年轻的参与者组(25-34岁)表现出最高的致敏负担,其中18.2%的人对10个或更多过敏原组具有IgE。无监督集群显示,24.4%的参与者中最大的一个集群也是医疗需求最高的一个,其特征是他们对呼吸源的多重敏感性。解释:我们分析大型生物样本数据集和健康信息的新方法可以测量普通人群的慢性炎症疾病负担,并确定需要更好医疗护理的最弱势群体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Novel, computational IgE-clustering in a population-based cross-sectional study: Mapping the allergy burden

Background

Even though the prevalence of allergies is increasing, population-based data are still scarce. As a read-out for chronic inflammatory information, new methods are needed to integrate individual biological measurements and lifestyle parameters to mitigate the consequences and costs of allergic burden for society.

Methods

More than 480.000 data points were collected from 1462 Luxembourg adults during the representative, cross-sectional European Health Examination Survey, spanning health and lifestyle reports. Deep IgE-profiles based on unsupervised clustering were correlated with data of the health survey.

Findings

42.6% of the participants reported a physician-diagnosed allergy and 44% were found to be IgE-positive to at least one allergen or extract. The main sensitization sources were tree pollens followed by grass pollens and mites (52.4%, 51.8% and 40.3% of sensitized participants respectively), suggesting seasonal as well as perennial burden. The youngest group of participants (25–34 years old) showed the highest burden of sensitization, with 18.2% of them having IgE to 10 or more allergen groups. Unsupervised clustering revealed that the biggest cluster of 24.4% of participants was also the one with the highest medical need, marked by their multi-sensitization to respiratory sources.

Interpretation

Our novel approach to analyzing large biosample datasets together with health information allows the measurement of the chronic inflammatory disease burden in the general population and led to the identification of the most vulnerable groups in need of better medical care.

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来源期刊
Clinical and Translational Allergy
Clinical and Translational Allergy Immunology and Microbiology-Immunology
CiteScore
7.50
自引率
4.50%
发文量
117
审稿时长
12 weeks
期刊介绍: Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.
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