m5C RNA甲基转移酶NOP2在高级别浆液性卵巢癌中的作用。

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL ACS Applied Energy Materials Pub Date : 2023-12-31 Epub Date: 2023-10-06 DOI:10.1080/15384047.2023.2263921

Shimin Yang, Dongmei Zhou, Chunxiao Zhang, Jiangdong Xiang, Xiaowei Xi

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引用次数: 0

摘要

核糖核酸甲基转移酶核仁蛋白p120（NOP2），通常被称为NOP2/Sun核糖核酸甲基转换酶家族成员1（NSUN1），参与细胞增殖，并在各种癌症中高度表达。然而，它在高级别癌症（HGSOC）中的作用尚不清楚。我们的研究调查了NOP2在HGSOC组织和正常伞组织中的表达，发现NOP2在HGSOC组织中显著上调。我们的实验表明，NOP2过表达在体内外促进了细胞增殖，并在体外增加了HGSOC细胞的迁移和侵袭能力。此外，我们确定Rap鸟嘌呤核苷酸交换因子4（RAPGEF4）是HGSOC中NOP2的潜在下游靶标。最后，我们的研究结果表明，NOP2和RAPGEF4的调节可能取决于m5C甲基化水平。

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Function of m⁵C RNA methyltransferase NOP2 in high-grade serous ovarian cancer.

RNA methyltransferase nucleolar protein p120 (NOP2), commonly referred to as NOP2/Sun RNA methyltransferase family member 1 (NSUN1), is involved in cell proliferation and is highly expressed in various cancers. However, its role in high-grade serous ovarian cancer (HGSOC) remains unclear. Our study investigated the expression of NOP2 in HGSOC tissues and normal fimbria tissues, and found that NOP2 was significantly upregulated in HGSOC tissues. Our experiments showed that NOP2 overexpression promoted cell proliferation in vivo and in vitro and increased the migration and invasion ability of HGSOC cells in vitro. Furthermore, we identified Rap guanine nucleotide exchange factor 4 (RAPGEF4) as a potential downstream target of NOP2 in HGSOC. Finally, our findings suggest that the regulation of NOP2 and RAPGEF4 may depend on m⁵C methylation levels.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.