癌症转移中环状RNA的新发现:最新进展。

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Non-Coding RNA Pub Date : 2023-09-16 DOI:10.3390/ncrna9050055
Paola Zepeda-Enríquez, Macrina B Silva-Cázares, César López-Camarillo
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引用次数: 0

摘要

环状RNA(circRNA)是单链闭合的非编码RNA分子,在人类癌症中异常表达并产生肿瘤特异性基因特征。它们通过充当转录调节因子、微小RNA海绵和蛋白质支架发挥生物功能,调节蛋白质-RNA复合物的形成,并最终调节基因表达。癌症三阴性(TNBC)是最具侵袭性的乳腺癌之一,预后不良。对circRNAs在TNBC中的研究是有限的,但已经证明了这些分子在细胞增殖、侵袭、转移和化疗/放疗耐药性中的关键作用,这表明它们可能是潜在的预后生物标志物和新的治疗靶点。在这里,我们回顾了关于circRNA生物发生和功能的实际知识现状,并总结了关于它们在TNBC发展和进展中的作用的新发现。此外,我们还讨论了外泌体在TNBC中circRNA转运和输出中的重要性的最新数据。对circRNA在转移和治疗反应中的功能的深入了解可能是确定新的治疗靶点以推进TNBC治疗的宝贵指南。
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Novel Insights into Circular RNAs in Metastasis in Breast Cancer: An Update.

Circular RNAs (circRNAs) are single-stranded closed non-coding RNA molecules that are aberrantly expressed and produce tumor-specific gene signatures in human cancers. They exert biological functions by acting as transcriptional regulators, microRNA sponges, and protein scaffolds, regulating the formation of protein-RNA complexes and, ultimately, regulating gene expression. Triple-negative breast cancer (TNBC) is one of the most aggressive cancers of the mammary gland and has a poor prognosis. Studies of circRNAs in TNBC are limited but have demonstrated these molecules' pivotal roles in cell proliferation, invasion, metastasis, and resistance to chemo/radiotherapy, suggesting that they could be potential prognostic biomarkers and novel therapeutic targets. Here, we reviewed the status of actual knowledge about circRNA biogenesis and functions and summarized novel findings regarding their roles in TNBC development and progression. In addition, we discussed recent data about the importance of exosomes in the transport and export of circRNAs in TNBC. Deep knowledge of circRNA functions in metastasis and therapy responses could be an invaluable guide in the identification of novel therapeutic targets for advancing the treatment of TNBC.

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来源期刊
Non-Coding RNA
Non-Coding RNA Biochemistry, Genetics and Molecular Biology-Genetics
CiteScore
6.70
自引率
4.70%
发文量
74
审稿时长
10 weeks
期刊介绍: Functional studies dealing with identification, structure-function relationships or biological activity of: small regulatory RNAs (miRNAs, siRNAs and piRNAs) associated with the RNA interference pathway small nuclear RNAs, small nucleolar and tRNAs derived small RNAs other types of small RNAs, such as those associated with splice junctions and transcription start sites long non-coding RNAs, including antisense RNAs, long ''intergenic'' RNAs, intronic RNAs and ''enhancer'' RNAs other classes of RNAs such as vault RNAs, scaRNAs, circular RNAs, 7SL RNAs, telomeric and centromeric RNAs regulatory functions of mRNAs and UTR-derived RNAs catalytic and allosteric (riboswitch) RNAs viral, transposon and repeat-derived RNAs bacterial regulatory RNAs, including CRISPR RNAS Analysis of RNA processing, RNA binding proteins, RNA signaling and RNA interaction pathways: DICER AGO, PIWI and PIWI-like proteins other classes of RNA binding and RNA transport proteins RNA interactions with chromatin-modifying complexes RNA interactions with DNA and other RNAs the role of RNA in the formation and function of specialized subnuclear organelles and other aspects of cell biology intercellular and intergenerational RNA signaling RNA processing structure-function relationships in RNA complexes RNA analyses, informatics, tools and technologies: transcriptomic analyses and technologies development of tools and technologies for RNA biology and therapeutics Translational studies involving long and short non-coding RNAs: identification of biomarkers development of new therapies involving microRNAs and other ncRNAs clinical studies involving microRNAs and other ncRNAs.
期刊最新文献
Cardiomyopathies: The Role of Non-Coding RNAs. MicroRNA Biogenesis, Gene Regulation Mechanisms, and Availability in Foods. Interplay of microRNAs and circRNAs in Epithelial Ovarian Cancer. Non-Coding RNA as a Biomarker in Lung Cancer. Back to the Origin: Mechanisms of circRNA-Directed Regulation of Host Genes in Human Disease.
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