高血压患者的血清kisspeptin高于非高血压女性受试者,并且与收缩压呈正相关。

IF 2.5 Q3 ENDOCRINOLOGY & METABOLISM Minerva endocrinology Pub Date : 2023-09-21 DOI:10.23736/S2724-6507.22.03766-6
Chantacha Sitticharoon, Yanint Raksadawan, Peerada Boonpuan, Issarawan Keadkraichaiwat, Rungnapa Sririwichitchai, Pailin Maikaew
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引用次数: 0

摘要

背景:Kisspeptin在生殖调控中发挥重要作用。此外,它还参与代谢和心血管调节,是一种强效的血管收缩剂。本研究旨在:1)确定血清kisspeptin水平与肥胖/代谢参数之间的相关性;2) 比较非高血压([non-HT]N.=15)和高血压([HT]N.=15)女性受试者之间的参数;以及3)确定瘦素、收缩压(SBP)或舒张压(DBP)与肥胖和代谢因素之间的相关性。方法:收集接受腹部直视手术的女性的临床参数、空腹血液和脂肪组织样本。结果:血清kisspeptin与肥胖参数无关,仅与SBP呈正相关(P结论:kisspeutin、肥胖尤其是内脏脂肪和胰岛素抵抗可能导致血压升高。需要进一步研究揭示kisspentin对代谢和心血管调节的潜在机制。
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Serum kisspeptin is higher in hypertensive than non-hypertensive female subjects and positively correlated with systolic blood pressure.

Background: Kisspeptin has a major role in reproductive regulation. Furthermore, it is also involved in metabolic and cardiovascular regulation as well as is a potent vasoconstrictor. This study aimed to: 1) determine correlations between serum kisspeptin levels with obesity/metabolic parameters; 2) compare parameters between non-hypertensive ([non-HT] N.=15) and hypertensive ([HT] N.=15) female subjects; and 3) determine correlations between leptin, systolic blood pressure (SBP) or diastolic blood pressure (DBP) with obesity and metabolic factors.

Methods: Clinical parameters and fasting blood and adipose tissue samples were collected from women undergoing open abdominal surgery.

Results: Serum kisspeptin was not correlated with obesity parameters but was positively correlated with only SBP (P<0.05). Serum kisspeptin, SBP, DBP, body weight, waist circumference, hip circumference, plasma glucose, plasma insulin, the homeostatic model assessment for insulin resistance (HOMA-IR), and height of visceral adipocytes (VA) were higher but the Quantitative Insulin Sensitivity Check Index (QUICKI) was lower in hypertensive compared to non-hypertensive female subjects (P<0.05). Leptin was positively correlated with obesity and metabolic paramters including area, width, and perimeter of subcutaneous adipocytes, and area, width, height, and perimeter of VA (P<0.05) but was negatively correlated the QUICKI (P<0.001). SBP had positive correlations with insulin, glucose, HOMA-IR, and kisspeptin, but had a negative correlation with QUICKI (P<0.05). DBP had positive correlations with body weight, BMI, waist circumference, hip circumference, insulin, glucose, HOMA-IR, and width of VA (P<0.05), but had a negative correlation with the QUICKI (P<0.05).

Conclusions: Kisspeptin, obesity especially visceral adiposity, and insulin resistance might contribute to increased blood pressure. Further studies are required to reveal the underlying mechanism of kisspeptin on metabolic and cardiovascular regulation.

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