ceRNA网络在妇科癌症进展和耐药性中的作用。

IF 4.3 4区医学 Q1 PHARMACOLOGY & PHARMACY Journal of Drug Targeting Pub Date : 2023-12-01 Epub Date: 2023-11-16 DOI:10.1080/1061186X.2023.2261079

Shuqin Wu, Baoshan Zhong, Yuxin Yang, Yurou Wang, Zezheng Pan

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引用次数: 0

摘要

妇科癌症是女性癌症中第二常见的类型。由于缺乏对其肿瘤发生机制和特异性诊断生物标志物的深入了解，这些癌症的临床诊断往往被延迟或误诊。许多研究表明，竞争性内源性RNA（ceRNA）通过微小RNA（miRNA）介导的机制调节妇科癌症的进展和耐药性，从而影响多种癌症相关途径中的基因表达。在这里，我们回顾了关于ceRNA假说参与妇科癌症进展和耐药性的研究，以验证一些ceRNA作为治疗靶点和预测生物标志物。

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ceRNA networks in gynecological cancers progression and resistance.

Gynecological cancers are the second most common types of cancer in women. Clinical diagnosis of these cancers is often delayed or misdiagnosed due to lack of insight into their tumorigenesis mechanism and specific diagnostic biomarkers. Many studies have demonstrated that competing endogenous RNAs (ceRNAs) modulate the progression and resistance of gynecological cancer through microRNA (miRNA)-mediated mechanisms, which affect gene expression in multiple cancer-related pathways. Here we review studies on the involvement of the ceRNA hypothesis in the progression and resistance of gynaecological cancers to validate some ceRNAs as therapeutic targets and predictive biomarkers.

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来源期刊

Journal of Drug Targeting 医学-药学

CiteScore

9.10

自引率

0.00%

发文量

165

审稿时长

2 months

期刊介绍： Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns.