癌症妇女代谢综合征危险因素与免疫组织化学特征的相关性。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Iranian Journal of Medical Sciences Pub Date : 2023-09-01 DOI:10.30476/IJMS.2022.95039.2673
Hiva Danesh, Robab Anbiaei, Nasrin Ziamajidi, Maryam Farhadian, Zeinab Barartabar, Roghayeh Abbasalipourkabir
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引用次数: 0

摘要

背景:代谢综合征(MetS)与乳腺癌症之间的相关性可能显著影响癌症的死亡率和发病率。本研究旨在评估癌症妇女的MetS危险因素与免疫组织化学(IHC)谱之间的关系。方法:本横断面研究使用了伊朗德黑兰Anbiai医生化疗和放射治疗诊所(2020-2021年)300名平均年龄为53.11±12.97岁的癌症患者的医疗记录。将这些病例分为五个亚组,包括管腔A、管腔B(HER-2-)、腔B(HER-2+)、HER-2过表达和三阴性。结果:癌症妇女有无MetS的预后指标没有差异。在患有MetS的女性中,观察到管腔A肿瘤(39.3%)、管腔B肿瘤(HER-2+)(25%)、三阴性(17%)、管腔B肿瘤(HER-2-)(10.7%)和HER-2过表达(8%)的比例高于未患有MetS的女性。多因素logistic回归分析显示,患有代谢综合征的患者发生管腔a的几率比没有代谢综合征患者高41%,BMI≥30 Kg/m2的患者患管腔B(HER-2+)的几率比患有BMI2的患者高80%。此外,腰围大于88 cm的女性患Luminal B(HER-2+)的几率比腰围小于88 cm的患者低14%。结论:MetS患者和非MetS患者的预后指标和IHC特征没有差异。
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Association between Metabolic Syndrome Risk Factors and Immunohistochemical Profile in Women with Breast Cancer.

Background: The association between metabolic syndrome (MetS) and breast cancer may significantly impact the mortality and incidence of breast cancer. This study aimed to assess the association between MetS risk factors and immunohistochemical (IHC) profiles in women with breast cancer.

Methods: This cross-sectional study used the medical records of 300 breast cancer patients with an average age of 53.11±12.97 years in the Chemotherapy and Radiation Therapy Clinic of Dr. Anbiai, Tehran, Iran (2020-2021). The cases were divided into five subgroups including luminal A, luminal B (HER-2-), luminal B (HER-2+), HER-2 overexpressing, and triple negative.

Results: There was no difference in the prognostic indicators between the presence and absence of MetS in women with breast cancer. A higher proportion of luminal A tumors (39.3%), luminal B (HER-2+) (25%), triple-negative (17%), luminal B (HER-2-) (10.7%), HER-2 overexpression (8%) was observed in women with MetS than those without MetS. Multivariate logistic regression analysis showed that patients with MetS had a 41% higher chance of developing luminal A than those without MetS, and patients with a BMI≥30 Kg/m2 had an 80% higher chance of developing luminal B (HER-2+) than those with a BMI<30 Kg/m2. Moreover, women with a waist circumference higher than 88 cm had a 14 % lower chance of developing Luminal B (HER-2+) than those with a waist circumference less than 88 cm.

Conclusion: There was no difference in prognostic indicators and IHC profile in patients with and without MetS.

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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