糖尿病前期是不良心脏事件的一个增加的危险因素:一项全国性的分析

IF 1.4 Q3 PERIPHERAL VASCULAR DISEASE Atherosclerosis plus Pub Date : 2023-09-14 DOI:10.1016/j.athplu.2023.08.002
Dhairya Nanavaty , Rhea Green , Ankushi Sanghvi , Rishav Sinha , Sohrab Singh , Tushar Mishra , Pradeep Devarakonda , Kendall Bell , Cesar Ayala Rodriguez , Kanwal Gambhir , Chadi Alraies , Sarath Reddy
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引用次数: 0

摘要

背景和目的糖尿病是指葡萄糖代谢受损的状态,血红蛋白A1c(HbA1c)水平高于糖尿病状态。越来越多的证据表明,糖尿病前期的高血糖紊乱甚至在进展为显性糖尿病之前就会导致微血管和大血管并发症。我们的目的是确定糖尿病前期与急性心血管事件的关系。方法我们利用2018-2020年全国住院患者样本,在排除所有糖尿病住院患者后,确定糖尿病前期的成人住院患者。使用分类变量的卡方检验和连续变量的t检验,比较糖尿病前期和非糖尿病前期住院患者的人口统计学和其他心血管风险因素的患病率。进一步进行多元回归分析,研究糖尿病前期对急性冠状动脉综合征、急性缺血性中风、颅内出血和急性心力衰竭的影响。结果糖尿病前期住院患者心血管危险因素的患病率较高,如高血压、高脂血症、肥胖和吸烟。此外,调整后的分析显示,与没有糖尿病前期的住院患者相比,糖尿病前期住院患者患急性冠状动脉综合征(OR-2.01;C.I:1.94-2.08;P<;0.001)、急性缺血性中风(OR-2.21;2.11-2.31;P<:0.001)和急性心力衰竭(OR-1.41;C.I:1.29-1.55;P<)的几率更高。结论我们的研究表明,糖尿病前期与发生重大心血管事件的几率较高有关。应进行进一步的前瞻性研究,以确定糖尿病前期是这些事件的独立致病因素。此外,应鼓励对糖尿病前期患者进行筛查和改变生活方式,以改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Prediabetes is an incremental risk factor for adverse cardiac events: A nationwide analysis

Background and aims

Prediabetes is defined as a state of impaired glucose metabolism with hemoglobin A1c (HbA1c) levels that precede those of a diabetic state. There is increasing evidence that suggests that hyperglycemic derangement in prediabetes leads to microvascular and macrovascular complications even before progression to overt diabetes mellitus. We aim to identify the association of prediabetes with acute cardiovascular events.

Methods

We utilized the National inpatient sample 2018-2020 to identify adult hospitalizations with prediabetes after excluding all hospitalizations with diabetes. Demographics and prevalence of other cardiovascular risk factors were compared in hospitalizations with and without prediabetes using the chi-square test for categorical variables and the t-test for continuous variables. Multivariate regression analysis was further performed to study the impact of prediabetes on acute coronary syndrome, acute ischemic stroke, intracranial hemorrhage, and acute heart failure.

Results

Hospitalizations with prediabetes had a higher prevalence of cardiovascular risk factors like hypertension, hyperlipidemia, obesity, and tobacco abuse. In addition, the adjusted analysis revealed that hospitalizations with prediabetes were associated with higher odds of developing acute coronary syndrome (OR-2.01; C.I:1.94-2.08; P<0.001), acute ischemic stroke (OR-2.21; 2.11-2.31; p<0.001), and acute heart failure (OR-1.41; C.I.: 1.29-1.55; p<0.001) as compared to hospitalizations without prediabetes.

Conclusions

Our study suggests that prediabetes is associated with a higher odds of major cardiovascular events. Further prospective studies should be conducted to identify prediabetes as an independent causative factor for these events. In addition, screening and lifestyle modifications for prediabetics should be encouraged to improve patient outcomes.

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来源期刊
Atherosclerosis plus
Atherosclerosis plus Cardiology and Cardiovascular Medicine
CiteScore
2.60
自引率
0.00%
发文量
0
审稿时长
66 days
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