FOXP转录因子的功能及其通过翻译后修饰的调节。

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2023-10-04 DOI:10.1016/j.bbagrm.2023.194992

Congwen Gao , Honglin Zhu , Peng Gong , Chen Wu , Xingzhi Xu , Xuefei Zhu

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引用次数: 0

摘要

转录因子的叉头盒亚家族P（FOXP）由FOXP1、FOXP2、FOXP3和FOXP4组成，参与多系统功能的调节。FOXP蛋白转录活性的破坏导致神经发育障碍和免疫疾病，以及抑制或促进致癌作用。FOXP蛋白的转录活性直接或间接受到各种翻译后修饰的调节，包括磷酸化、泛素化、SUMO化、乙酰化、O-GlcNAcylation和甲基化。在此，我们讨论了翻译后修饰如何调节FOXP蛋白的多种功能，并研究了其对肿瘤发生和癌症治疗的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The functions of FOXP transcription factors and their regulation by post-translational modifications

The forkhead box subfamily P (FOXP) of transcription factors, consisting of FOXP1, FOXP2, FOXP3, and FOXP4, is involved in the regulation of multisystemic functioning. Disruption of the transcriptional activity of FOXP proteins leads to neurodevelopmental disorders and immunological diseases, as well as the suppression or promotion of carcinogenesis. The transcriptional activities of FOXP proteins are directly or indirectly regulated by diverse post-translational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, O-GlcNAcylation, and methylation. Here, we discuss how post-translational modifications modulate the multiple functions of FOXP proteins and examine the implications for tumorigenesis and cancer therapy.

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来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.